PMID- 23148082
OWN - NLM
STAT- MEDLINE
DCOM- 20140214
LR  - 20191210
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Linking)
VI  - 14
IP  - 6
DP  - 2013 Jun
TI  - Layer-specific analysis of myocardial deformation for assessment of infarct 
      transmurality: comparison of strain-encoded cardiovascular magnetic resonance 
      with 2D speckle tracking echocardiography.
PG  - 570-8
LID - 10.1093/ehjci/jes229 [doi]
AB  - AIMS: Separate analysis of endocardial and epicardial myocardial layer 
      deformation has become possible using strain-encoded cardiovascular magnetic 
      resonance (SENC) and 2D-dimensional speckle tracking echocardiography (Echo). 
      This study evaluated and compared both modalities for the assessment of infarct 
      transmurality as defined by late gadolinium enhancement (LGE) cardiovascular 
      magnetic resonance (CMR). METHODS AND RESULTS: In 29 patients (age 62.4 +/- 11.7 
      years, 23 male) with ischaemic cardiomyopathy, SENC using 1.5 T CMR and Echo were 
      performed. Peak circumferential systolic strain of the endocardial and the 
      epicardial layer of 304 myocardial segments was assessed by SENC and by Echo. The 
      segmental transmurality of myocardial infarction was determined as relative 
      amount of LGE (0%: no infarction; 1-50%: non-transmural infarction; 51-100%: 
      transmural infarction). Endocardial and epicardial strain defined by SENC and by 
      Echo differed significantly between segments of different infarct transmurality 
      determined by CMR. Endocardial layer circumferential strain analysis by Echo and 
      by SENC allowed distinction of segments with non-transmural infarction from 
      non-infarcted segments with similar accuracy [area under the curve (AUC) 0.699 
      vs. 0.649, respectively, P = 0.239]. Epicardial layer circumferential strain 
      analysis by Echo and by SENC allowed distinction of transmural from 
      non-transmural myocardial infarction defined by LGE CMR with similar accuracy 
      (AUC 0.721 vs. 0.664, respectively, P = 0.401). Endocardial strain by SENC 
      correlated moderately with endocardial strain by Echo (r = 0.50; standard error 
      of estimate = 5.2%). CONCLUSION: Layer-specific analysis of myocardial 
      deformation by Echo and by SENC allows discrimination between different 
      transmurality categories of myocardial infarction with similar accuracy. However, 
      accuracy of both methods is non-optimal, indicating that further tools for 
      improvement should be evaluated in the future.
FAU - Altiok, Ertunc
AU  - Altiok E
AD  - Department of Cardiology, Pneumology and Angiology, University Hospital RWTH 
      Aachen, Aachen, Germany.
FAU - Neizel, Mirja
AU  - Neizel M
FAU - Tiemann, Sonja
AU  - Tiemann S
FAU - Krass, Vitali
AU  - Krass V
FAU - Becker, Michael
AU  - Becker M
FAU - Zwicker, Christian
AU  - Zwicker C
FAU - Koos, Ralf
AU  - Koos R
FAU - Kelm, Malte
AU  - Kelm M
FAU - Kraemer, Nils
AU  - Kraemer N
FAU - Schoth, Felix
AU  - Schoth F
FAU - Marx, Nikolaus
AU  - Marx N
FAU - Hoffmann, Rainer
AU  - Hoffmann R
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20121112
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Cohort Studies
MH  - Echocardiography/*methods
MH  - Echocardiography, Doppler, Color/methods
MH  - Endocardium/diagnostic imaging/pathology
MH  - Female
MH  - Gadolinium
MH  - Humans
MH  - *Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnostic imaging/*pathology
MH  - Myocardial Ischemia/diagnostic imaging/pathology
MH  - Observer Variation
MH  - Pericardium/diagnostic imaging/pathology
MH  - ROC Curve
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Cardiovascular magnetic resonance
OT  - Echocardiography
OT  - Myocardial contraction
EDAT- 2012/11/14 06:00
MHDA- 2014/02/15 06:00
CRDT- 2012/11/14 06:00
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2014/02/15 06:00 [medline]
AID - jes229 [pii]
AID - 10.1093/ehjci/jes229 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2013 Jun;14(6):570-8. doi: 10.1093/ehjci/jes229. 
      Epub 2012 Nov 12.