PMID- 23149657
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20221207
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 60
IP  - 3
DP  - 2013
TI  - Short duration of diabetes and disuse of sulfonylurea have any association with 
      insulin cessation of the patients with type 2 diabetes in a clinical setting in 
      Japan (JDDM 30).
PG  - 305-10
AB  - Insulin therapy is often required to achieve good glycemic control for the 
      patients with type 2 diabetes mellitus (T2DM), while protraction of glycemic 
      control without insulin therapy may be preferable for patients. To determine the 
      characteristics of and therapeutic regimen in outpatients with T2DM who were able 
      to stop insulin therapy with satisfactory glycemic control in a real clinical 
      practice setting in Japan by a case-control study. The present study was 
      performed on 928 patients with T2DM who started insulin therapy in 2007. Data 
      regarding age, sex, body mass index, duration of diabetes, HbA1c, postprandial 
      plasma glucose, plasma fasting C-peptide immunoreactivity and treatment modality 
      were compared between patients who were able to stop insulin therapy and those 
      who continued with insulin. Of the 928 patients, 37 had stopped insulin therapy 
      within 1 year. In the patients who stopped insulin therapy, the duration of 
      diabetes was significantly shorter and the daily insulin dosage at initiation and 
      the prevalence of sulfonylurea pretreatment significantly lower compared with 
      patients who continued on insulin. In conclusion, almost 4% of T2DM patients were 
      able to stop insulin therapy with satisfactory glycemic control in a real 
      clinical practice setting in Japan. Shorter duration of diabetes and disuse of 
      sulfonylureas prior to insulin may associate with stopping insulin therapy as a 
      near-normoglycemic remission in outpatients with T2DM in Japan.
FAU - Arai, Keiko
AU  - Arai K
AD  - Arai Clinic, Yokohama 227-0044, Japan. arai-cl@n04.itscom.net
FAU - Hirao, Koichi
AU  - Hirao K
FAU - Yamauchi, Mikio
AU  - Yamauchi M
FAU - Kobayashi, Masashi
AU  - Kobayashi M
FAU - Kashiwagi, Atsunori
AU  - Kashiwagi A
CN  - Japan Diabetes Clinical Data Management Study Group
LA  - eng
PT  - Journal Article
DEP - 20121110
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Sulfonylurea Compounds)
SB  - IM
MH  - Aged
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - C-Peptide/blood
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy
MH  - Fasting
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Insulin/*administration & dosage
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Postprandial Period
MH  - Sulfonylurea Compounds/*administration & dosage
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2012/11/15 06:00
MHDA- 2013/10/01 06:00
CRDT- 2012/11/15 06:00
PHST- 2012/11/15 06:00 [entrez]
PHST- 2012/11/15 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - DN/JST.JSTAGE/endocrj/EJ12-0324 [pii]
AID - 10.1507/endocrj.ej12-0324 [doi]
PST - ppublish
SO  - Endocr J. 2013;60(3):305-10. doi: 10.1507/endocrj.ej12-0324. Epub 2012 Nov 10.