PMID- 23150635
OWN - NLM
STAT- MEDLINE
DCOM- 20130821
LR  - 20211021
IS  - 1532-298X (Electronic)
IS  - 1040-4651 (Print)
IS  - 1040-4651 (Linking)
VI  - 24
IP  - 11
DP  - 2012 Nov
TI  - Arabidopsis FHY3 and HY5 positively mediate induction of COP1 transcription in 
      response to photomorphogenic UV-B light.
PG  - 4590-606
LID - 10.1105/tpc.112.103994 [doi]
AB  - As sessile organisms, higher plants have evolved the capacity to sense and 
      interpret diverse light signals to modulate their development. In Arabidopsis 
      thaliana, low-intensity and long-wavelength UV-B light is perceived as an 
      informational signal to mediate UV-B-induced photomorphogenesis. Here, we report 
      that the multifunctional E3 ubiquitin ligase, CONSTITUTIVE PHOTOMORPHOGENESIS1 
      (COP1), a known key player in UV-B photomorphogenic responses, is also a 
      UV-B-inducible gene. Two transcription factors, FAR-RED ELONGATED HYPOCOTYL3 
      (FHY3) and ELONGATED HYPOCOTYL5 (HY5), directly bind to distinct regulatory 
      elements within the COP1 promoter, which are essential for the induction of the 
      COP1 gene mediated by photomorphogenic UV-B signaling. Absence of FHY3 results in 
      impaired UV-B-induced hypocotyl growth and reduced tolerance against damaging 
      UV-B. Thus, FHY3 positively regulates UV-B-induced photomorphogenesis by directly 
      activating COP1 transcription, while HY5 promotes COP1 expression via a positive 
      feedback loop. Furthermore, FHY3 and HY5 physically interact with each other, and 
      this interaction is diminished by UV-B. Together, our findings reveal that COP1 
      gene expression in response to photomorphogenic UV-B is controlled by a 
      combinatorial regulation of FHY3 and HY5, and this UV-B-specific working mode of 
      FHY3 and HY5 is distinct from that in far-red light and circadian conditions.
FAU - Huang, Xi
AU  - Huang X
AD  - College of Life Sciences, Beijing Normal University, Beijing 100875, China.
FAU - Ouyang, Xinhao
AU  - Ouyang X
FAU - Yang, Panyu
AU  - Yang P
FAU - Lau, On Sun
AU  - Lau OS
FAU - Li, Gang
AU  - Li G
FAU - Li, Jigang
AU  - Li J
FAU - Chen, Haodong
AU  - Chen H
FAU - Deng, Xing Wang
AU  - Deng XW
LA  - eng
GR  - R01 GM047850/GM/NIGMS NIH HHS/United States
GR  - R37 GM047850/GM/NIGMS NIH HHS/United States
GR  - GM47850/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121113
PL  - England
TA  - Plant Cell
JT  - The Plant cell
JID - 9208688
RN  - 0 (Anthocyanins)
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (FHY3 protein, Arabidopsis)
RN  - 0 (HY5 protein, Arabidopsis)
RN  - 0 (Nuclear Proteins)
RN  - 11121-56-5 (Phytochrome)
RN  - EC 2.3.2.27 (AT2G32950 protein, Arabidopsis)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Anthocyanins/metabolism
MH  - Arabidopsis/*genetics/metabolism/*radiation effects
MH  - Arabidopsis Proteins/*genetics/metabolism
MH  - Basic-Leucine Zipper Transcription Factors/genetics/metabolism
MH  - *Gene Expression Regulation, Plant
MH  - Hypocotyl/genetics/metabolism/radiation effects
MH  - Models, Molecular
MH  - Nuclear Proteins/genetics/metabolism
MH  - Nucleotide Motifs
MH  - Phenotype
MH  - Phytochrome/genetics/metabolism
MH  - Promoter Regions, Genetic/genetics
MH  - Protein Binding
MH  - Seedlings/genetics/metabolism/radiation effects
MH  - Sequence Deletion
MH  - Signal Transduction
MH  - Time Factors
MH  - Transcriptional Activation
MH  - Two-Hybrid System Techniques
MH  - Ubiquitin-Protein Ligases/genetics/metabolism
MH  - *Ultraviolet Rays
PMC - PMC3531854
EDAT- 2012/11/15 06:00
MHDA- 2013/08/22 06:00
PMCR- 2012/11/13
CRDT- 2012/11/15 06:00
PHST- 2012/11/15 06:00 [entrez]
PHST- 2012/11/15 06:00 [pubmed]
PHST- 2013/08/22 06:00 [medline]
PHST- 2012/11/13 00:00 [pmc-release]
AID - tpc.112.103994 [pii]
AID - 103994 [pii]
AID - 10.1105/tpc.112.103994 [doi]
PST - ppublish
SO  - Plant Cell. 2012 Nov;24(11):4590-606. doi: 10.1105/tpc.112.103994. Epub 2012 Nov 
      13.