PMID- 23151611
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20130422
IS  - 1461-7285 (Electronic)
IS  - 0269-8811 (Linking)
VI  - 27
IP  - 5
DP  - 2013 May
TI  - Antidepressant-like effect of oleanolic acid in mice exposed to the repeated 
      forced swimming test.
PG  - 459-68
LID - 10.1177/0269881112467090 [doi]
AB  - The study aimed to explore the antidepressant-like effect of oleanolic acid and 
      its possible mechanism related to the monoaminergic system and neurotrophin in 
      mice exposed to the repeated forced swimming test (FST). Both the duration and 
      the latency of immobility affected by oleanolic acid (10, 20 and 40 mg/kg) were 
      evaluated in the FST repeated at intervals on days 1, 7 and 14, followed by 
      neurochemical and brain-derived neurotrophic factor (BDNF) analyses in the mouse 
      brain regions of frontal cortex and whole hippocampus. A repeated analysis of 
      variance (ANOVA) indicated that over retesting the immobility time increased, 
      whereas latency to immobility tended to decrease. Minute-by-minute analysis 
      showed that immobility time also increased during the 4-min course of the test. 
      In addition, post-hoc Dunnett's test demonstrated that sub-chronic and chronic, 
      but not acute, oleanolic acid treatment reduced the immobility time (sub-chronic: 
      20 mg/kg, 43.5%; chronic: 10 mg/kg, 19.3%; 20 mg/kg, 31.8%) and increased the 
      latency to immobility (sub-chronic: 10 mg/kg, 60.6%; 20 mg/kg, 80.1%; chronic: 10 
      mg/kg, 121.8%; 20 mg/kg, 140.8%; 40 mg/kg, 80.0%). Furthermore, chronic 
      administration of oleanolic acid significantly increased serotonin (5-HT) levels 
      (frontal cortex: 44.5%, 41.9%, 27.5% for 10, 20, 40 mg/kg; hippocampus: 57.2%, 
      80.9% for 10, 20 mg/kg), decreased 5-hydroxyindoleacetic acid (5-HIAA)/5-HT ratio 
      (frontal cortex: 31.6%, 30.1%, 23.5%; hippocampus: 40.6%, 47.7%, 29.2% for 10, 
      20, 40 mg/kg) and elevated norepinephrine (NE) levels (hippocampus: 20 mg/kg, 
      45.4%) but did not alter dopamine (DA) levels. Moreover, BDNF levels in the two 
      brain regions were also elevated by chronic oleanolic acid treatment (frontal 
      cortex: 20 mg/kg, 67.2%; hippocampus: 10 mg/kg, 36.4%; 20 mg/kg, 55.1%). Taken 
      together, these findings imply that functions of 5-HT, NE and BDNF may be 
      involved in the antidepressant-like effect of oleanolic acid.
FAU - Yi, Li-Tao
AU  - Yi LT
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen, PR China. litao.yi@yahoo.com
FAU - Li, Jing
AU  - Li J
FAU - Liu, Qing
AU  - Liu Q
FAU - Geng, Di
AU  - Geng D
FAU - Zhou, Ya-Fei
AU  - Zhou YF
FAU - Ke, Xiao-Qing
AU  - Ke XQ
FAU - Chen, Huan
AU  - Chen H
FAU - Weng, Lian-Jin
AU  - Weng LJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121113
PL  - United States
TA  - J Psychopharmacol
JT  - Journal of psychopharmacology (Oxford, England)
JID - 8907828
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 333DO1RDJY (Serotonin)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - 6SMK8R7TGJ (Oleanolic Acid)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Dopamine/metabolism
MH  - Frontal Lobe/drug effects/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Motor Activity/*drug effects
MH  - Norepinephrine/metabolism
MH  - Oleanolic Acid/*pharmacology
MH  - Serotonin/metabolism
MH  - Stress, Physiological/*drug effects
MH  - *Swimming
EDAT- 2012/11/16 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/16 06:00
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 0269881112467090 [pii]
AID - 10.1177/0269881112467090 [doi]
PST - ppublish
SO  - J Psychopharmacol. 2013 May;27(5):459-68. doi: 10.1177/0269881112467090. Epub 
      2012 Nov 13.