PMID- 23152341
OWN - NLM
STAT- MEDLINE
DCOM- 20130712
LR  - 20190907
IS  - 1678-9849 (Electronic)
IS  - 0037-8682 (Linking)
VI  - 45
IP  - 5
DP  - 2012 Oct
TI  - Paracoccidioidomycosis case series with and without central nervous system 
      involvement.
PG  - 586-90
LID - S0037-86822012000500009 [pii]
AB  - INTRODUCTION: Paracoccidioidomycosis (PCM) is the most important systemic mycosis 
      in South America. Central nervous system involvement is potentially fatal and can 
      occur in 12.5% of cases. This paper aims to contribute to the literature 
      describing eight cases of neuroparacoccidioidomycosis (NPMC) and compare their 
      characteristics with patients without neurological involvement, to identify 
      unique characteristics of NPCM. METHODS: A cohort of 213 PCM cases was evaluated 
      at the Infectious Diseases Clinic of the University Hospital, Federal University 
      of Minas Gerais, Brazil, from October 1976 to August 2008. Epidemiological, 
      clinical, laboratory, therapeutic and follow-up data were registered. RESULTS: 
      Eight patients presented NPCM. The observed NPCM prevalence was 3.8%. One patient 
      presented the subacute form of PCM and the other seven presented the chronic form 
      of the disease. The parenchymatous form of NPCM occurred in all patients. 60% of 
      the patients who proceeded from the north/ northeast region of Minas Gerais State 
      developed NPCM. The neurological involvement of a mother and her son was 
      observed. NPCM patients exhibited demographical and clinical profiles similar to 
      what is described in the literature. When NPCM cases were compared to PCM 
      patients, there were differences in relation to origin and positive PCM family 
      history. CONCLUSIONS: The results corroborate the clinical view that the 
      neurological findings are extremely important in the evaluation of PCM patients. 
      Despite the limitations of this study, the differences in relation to patient's 
      origins and family history point to the need of further studies to determine the 
      susceptibility factors involved in the neurological compromise.
FAU - Pedroso, Vinicius Sousa Pietra
AU  - Pedroso VS
AD  - Programa de Pos-Graduacao em Infectologia e Medicina Tropical, Universidade 
      Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
FAU - Lyon, Ana Claudia
AU  - Lyon AC
FAU - Araujo, Stanley Almeida
AU  - Araujo SA
FAU - Veloso, Juliana Marcia Ribeiro
AU  - Veloso JM
FAU - Pedroso, Enio Roberto Pietra
AU  - Pedroso ER
FAU - Teixeira, Antonio Lucio
AU  - Teixeira AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Rev Soc Bras Med Trop
JT  - Revista da Sociedade Brasileira de Medicina Tropical
JID - 7507456
SB  - IM
MH  - Adult
MH  - Brain Diseases/diagnostic imaging/*epidemiology/microbiology
MH  - Brazil/epidemiology
MH  - Central Nervous System Fungal Infections/diagnostic 
      imaging/*epidemiology/microbiology
MH  - Chi-Square Distribution
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Paracoccidioidomycosis/diagnostic imaging/*epidemiology
MH  - Prevalence
MH  - Tomography, X-Ray Computed
MH  - Young Adult
EDAT- 2012/11/16 06:00
MHDA- 2013/07/16 06:00
CRDT- 2012/11/16 06:00
PHST- 2012/03/12 00:00 [received]
PHST- 2012/05/22 00:00 [accepted]
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2013/07/16 06:00 [medline]
AID - S0037-86822012000500009 [pii]
AID - 10.1590/s0037-86822012000500009 [doi]
PST - ppublish
SO  - Rev Soc Bras Med Trop. 2012 Oct;45(5):586-90. doi: 
      10.1590/s0037-86822012000500009.