PMID- 23152767
OWN - NLM
STAT- MEDLINE
DCOM- 20130501
LR  - 20231106
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 11
DP  - 2012
TI  - No association of the BDNF val66met polymorphism with implicit associative 
      vocabulary and motor learning.
PG  - e48327
LID - 10.1371/journal.pone.0048327 [doi]
LID - e48327
AB  - Brain-derived neurotrophic factor (BDNF) has been suggested to play a major role 
      in plasticity, neurogenesis and learning in the adult brain. The BDNF gene 
      contains a common val66met polymorphism associated with decreased 
      activity-dependent excretion of BDNF and a potential influence on behaviour, more 
      specifically, on motor learning. The objective of this study was to determine the 
      influence of the BDNF val66met polymorphism on short-term implicit associative 
      learning and whether its influence is cognitive domain-specific (motor vs. 
      language). A sample of 38 young healthy participants was genotyped, screened for 
      background and neuropsychological differences, and tested with two associative 
      implicit learning paradigms in two different cognitive domains, i.e., motor and 
      vocabulary learning. Subjects performed the serial reaction time task (SRTT) to 
      determine implicit motor learning and a recently established associative 
      vocabulary learning task (AVL) for implicit learning of action and object words. 
      To determine the influence of the BDNF polymorphism on domain-specific implicit 
      learning, behavioural improvements in the two tasks were compared between val/val 
      (n = 22) and met carriers (val/met: n = 15 and met/met: n = 1). There was no 
      evidence for an impact of the BDNF val66met polymorphism on the behavioural 
      outcome in implicit short-term learning paradigms in young healthy subjects. 
      Whether this polymorphism plays a relevant role in long-term training paradigms 
      or in subjects with impaired neuronal plasticity or reduced learning capacity, 
      such as aged individuals, demented patients or patients with brain lesions, has 
      to be determined in future studies.
FAU - Freundlieb, Nils
AU  - Freundlieb N
AD  - Brain Imaging and Neurostimulation Laboratory, Department of Neurology, 
      University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
FAU - Philipp, Stephan
AU  - Philipp S
FAU - Schneider, Susanne A
AU  - Schneider SA
FAU - Bruggemann, Norbert
AU  - Bruggemann N
FAU - Klein, Christine
AU  - Klein C
FAU - Gerloff, Christian
AU  - Gerloff C
FAU - Hummel, Friedhelm C
AU  - Hummel FC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121113
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Amino Acid Substitution
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Learning/*physiology
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Psychomotor Performance/physiology
MH  - Reaction Time
MH  - Verbal Learning/physiology
MH  - Young Adult
PMC - PMC3496723
COIS- Competing Interests: NF reports having received a travel grant by the 
      "GlaxoSmithKline-Stiftung" to attend "SfN Neuroscience 2011" in Washington, D.C. 
      There are no patents, products in development or marketed products to declare. 
      This does not alter the authors' adherence to all the PLOS ONE policies on 
      sharing data and materials.
EDAT- 2012/11/16 06:00
MHDA- 2013/05/02 06:00
PMCR- 2012/11/13
CRDT- 2012/11/16 06:00
PHST- 2012/08/07 00:00 [received]
PHST- 2012/09/24 00:00 [accepted]
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2013/05/02 06:00 [medline]
PHST- 2012/11/13 00:00 [pmc-release]
AID - PONE-D-12-23799 [pii]
AID - 10.1371/journal.pone.0048327 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(11):e48327. doi: 10.1371/journal.pone.0048327. Epub 2012 Nov 13.