PMID- 23153651
OWN - NLM
STAT- MEDLINE
DCOM- 20130820
LR  - 20131121
IS  - 1095-6840 (Electronic)
IS  - 0016-6480 (Linking)
VI  - 181
DP  - 2013 Jan 15
TI  - D-Aspartic acid implication in the modulation of frog brain sex steroid levels.
PG  - 72-6
LID - S0016-6480(12)00420-0 [pii]
LID - 10.1016/j.ygcen.2012.11.003 [doi]
AB  - There is evidence that D-aspartate (D-Asp) modulates sex hormone levels in frog 
      testis by regulating the activity of P450 aromatase (P450 aro), the key enzyme 
      which converts Testosterone (T) in 17ss-Estradiol (E2). Here we report, for the 
      first time, that there is a direct correlation among brain levels of D-Asp, P450 
      aro, E2 and Estradiol Receptor (ERalpha) in the male frogs during the reproductive as 
      well as the post-reproductive phases of the breeding cycle, with highest levels 
      being observed in the post-reproductive period. D-Asp i.p. administration to 
      frogs ready for reproduction, induced an increase of brain P450 aro protein 
      expression with concomitant enhancement of both E2 levels and ERalpha expression; at 
      the same time, brain T levels and Androgen receptor expression decreased. In 
      contrast, in the post-reproductive frogs, D-Asp treatment did not modify any of 
      these parameters. Taken together, these results imply that the regulation of P450 
      aro expression by D-Asp could be an important step in the control of E2 levels in 
      the frog brain.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Santillo, Alessandra
AU  - Santillo A
AD  - Dipartimento di Scienze della Vita, Seconda Universita di Napoli, Via Vivaldi 43, 
      81100 Caserta, Italy.
FAU - Pinelli, Claudia
AU  - Pinelli C
FAU - Burrone, Lavinia
AU  - Burrone L
FAU - Chieffi Baccari, Gabriella
AU  - Chieffi Baccari G
FAU - Di Fiore, Maria Maddalena
AU  - Di Fiore MM
LA  - eng
PT  - Journal Article
DEP - 20121112
PL  - United States
TA  - Gen Comp Endocrinol
JT  - General and comparative endocrinology
JID - 0370735
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Receptors, Androgen)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Steroids)
RN  - 4SR0Q8YD1X (D-Aspartic Acid)
RN  - EC 1.14.14.1 (Aromatase)
SB  - IM
MH  - Animals
MH  - Anura/*metabolism
MH  - Aromatase/metabolism
MH  - Brain/*metabolism
MH  - D-Aspartic Acid/*metabolism
MH  - Gonadal Steroid Hormones/metabolism
MH  - Male
MH  - Receptors, Androgen/metabolism
MH  - Receptors, Estrogen/metabolism
MH  - Steroids/*metabolism
EDAT- 2012/11/17 06:00
MHDA- 2013/08/21 06:00
CRDT- 2012/11/17 06:00
PHST- 2012/03/31 00:00 [received]
PHST- 2012/10/26 00:00 [revised]
PHST- 2012/11/02 00:00 [accepted]
PHST- 2012/11/17 06:00 [entrez]
PHST- 2012/11/17 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
AID - S0016-6480(12)00420-0 [pii]
AID - 10.1016/j.ygcen.2012.11.003 [doi]
PST - ppublish
SO  - Gen Comp Endocrinol. 2013 Jan 15;181:72-6. doi: 10.1016/j.ygcen.2012.11.003. Epub 
      2012 Nov 12.