PMID- 23153709
OWN - NLM
STAT- MEDLINE
DCOM- 20130923
LR  - 20161125
IS  - 1873-281X (Electronic)
IS  - 1472-9792 (Linking)
VI  - 93
IP  - 2
DP  - 2013 Mar
TI  - Antituberculosis drug-induced hypersensitivity syndrome and its association with 
      human leukocyte antigen.
PG  - 270-4
LID - S1472-9792(12)00197-7 [pii]
LID - 10.1016/j.tube.2012.10.010 [doi]
AB  - Antituberculosis drug (ATD)-induced hypersensitivity syndrome (HSS) is a serious 
      adverse reaction to ATDs, but much remains to be determined regarding its 
      characteristics and genetic risk factors. In this study, we have collected cases 
      of ATD-induced HSS and their clinical features, and investigated the associations 
      of ATD-induced HSS with human leukocyte antigen (HLA). Subjects with ATD-induced 
      HSS and ATD-tolerant controls were recruited through analysis of a multicenter 
      adverse drug reaction registry in Korea. HLA allele frequencies were compared 
      between subjects with ATD-induced HSS (n = 14) and two control groups: 
      ATD-tolerant controls (n = 166) and the general population (n = 485). The number 
      of enrolled subjects with ATD-induced HSS (n = 14) was comparable to those of 
      patients with HSS induced by other common drugs such as allopurinol during the 
      recruitment period. The frequency of Cw*0401 was much higher in the cases (50.0%) 
      compared with ATD-tolerant controls (12.7%, Pc = 0.0204, OR = 6.90) and the 
      general population (12.8%, Pc = 0.0132, OR = 6.82). Our results suggest that ATD 
      is an important causative agent inducing HSS with distinct clinical features. The 
      strong association of Cw*0401 with the risk for ATD-induced HSS suggests 
      immunological involvement in the development of this syndrome.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Kim, Sang-Heon
AU  - Kim SH
AD  - Department of Internal Medicine, Hanyang University College of Medicine, 17 
      Haengdang-dong, Seongdong-gu, Seoul 133-792, South Korea. 
      sangheonkim@hanyang.ac.kr
FAU - Lee, Soo-Keol
AU  - Lee SK
FAU - Kim, Sang-Hoon
AU  - Kim SH
FAU - Park, Heung-Woo
AU  - Park HW
FAU - Chang, Yoon-Seok
AU  - Chang YS
FAU - Lee, Kyung Wha
AU  - Lee KW
FAU - Jee, Young-Koo
AU  - Jee YK
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20121113
PL  - Scotland
TA  - Tuberculosis (Edinb)
JT  - Tuberculosis (Edinburgh, Scotland)
JID - 100971555
RN  - 0 (Antitubercular Agents)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Adverse Drug Reaction Reporting Systems
MH  - Aged
MH  - Aged, 80 and over
MH  - Antitubercular Agents/*adverse effects
MH  - Case-Control Studies
MH  - Chemical and Drug Induced Liver Injury/etiology/genetics
MH  - Drug Eruptions/etiology/genetics
MH  - Drug Hypersensitivity/etiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Testing/methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2012/11/17 06:00
MHDA- 2013/09/24 06:00
CRDT- 2012/11/17 06:00
PHST- 2012/07/25 00:00 [received]
PHST- 2012/10/18 00:00 [revised]
PHST- 2012/10/22 00:00 [accepted]
PHST- 2012/11/17 06:00 [entrez]
PHST- 2012/11/17 06:00 [pubmed]
PHST- 2013/09/24 06:00 [medline]
AID - S1472-9792(12)00197-7 [pii]
AID - 10.1016/j.tube.2012.10.010 [doi]
PST - ppublish
SO  - Tuberculosis (Edinb). 2013 Mar;93(2):270-4. doi: 10.1016/j.tube.2012.10.010. Epub 
      2012 Nov 13.