PMID- 23154283
OWN - NLM
STAT- MEDLINE
DCOM- 20140102
LR  - 20211021
IS  - 2150-5608 (Electronic)
IS  - 2150-5594 (Print)
IS  - 2150-5594 (Linking)
VI  - 3
IP  - 7
DP  - 2012 Nov 15
TI  - The role of dendritic cells in Mycobacterium tuberculosis infection.
PG  - 654-9
LID - 10.4161/viru.22586 [doi]
AB  - The immune response against Mycobacterium tuberculosis is multifactorial, 
      involving a network of innate and adaptive immune responses. Characterization of 
      the immune response, a clear understanding of the dynamics and interplay of 
      different arms of the immune response are critical to allow the development of 
      better tools for combating tuberculosis. Dendritic cells (DCs) are one of the key 
      cells in bridging innate and adaptive immune response through their significant 
      role in capturing, processing and presenting antigens. The outcome of interaction 
      of M. tuberculosis with DCs is not fully understood and the available reports are 
      contradictory were some findings reported that DCs strengthen the cellular immune 
      response against mycobacterium infection whereas others reported M. tuberculosis 
      impairs the function of DCs were infected DCs are poor stimulators of M. 
      tuberculosis Ag-specific CD4 T cells. Other studies showed that the outcome 
      depends on M. tuberculosis strain type and type of receptor on DCs during 
      recognition. In this review I shall highlight the recent findings in the outcome 
      of interaction of Mycobacterium tuberculosis with DCs.
FAU - Mihret, Adane
AU  - Mihret A
AD  - Armauer Hansen Research Institute; Addis Ababa, Ethopia. adane_mihret@yahoo.com
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121115
PL  - United States
TA  - Virulence
JT  - Virulence
JID - 101531386
SB  - IM
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Dendritic Cells/*immunology/microbiology
MH  - Humans
MH  - Immune Evasion
MH  - Mycobacterium tuberculosis/*immunology/pathogenicity
MH  - Tuberculosis/*immunology/pathology
PMC - PMC3545947
OTO - NOTNLM
OT  - M. tuberculosis
OT  - T cells
OT  - activation
OT  - dendritic cells
OT  - maturation
EDAT- 2012/11/17 06:00
MHDA- 2014/01/03 06:00
PMCR- 2012/11/15
CRDT- 2012/11/17 06:00
PHST- 2012/11/17 06:00 [entrez]
PHST- 2012/11/17 06:00 [pubmed]
PHST- 2014/01/03 06:00 [medline]
PHST- 2012/11/15 00:00 [pmc-release]
AID - 22586 [pii]
AID - 2012VIRULENCE0041R1 [pii]
AID - 10.4161/viru.22586 [doi]
PST - ppublish
SO  - Virulence. 2012 Nov 15;3(7):654-9. doi: 10.4161/viru.22586. Epub 2012 Nov 15.