PMID- 23154307
OWN - NLM
STAT- MEDLINE
DCOM- 20130718
LR  - 20211203
IS  - 1423-0216 (Electronic)
IS  - 1021-7401 (Linking)
VI  - 20
IP  - 1
DP  - 2013
TI  - Perinatal periodontal disease reduces social behavior in male offspring.
PG  - 29-38
LID - 10.1159/000342987 [doi]
AB  - OBJECTIVE: Our objective was to verify whether prenatal maternal periodontitis is 
      a risk factor for the development of central nervous system disorders in rats. 
      METHODS: Periodontitis was induced by placing a ligature around the upper and 
      lower first molars in 9 female Wistar rats (experimental group); 9 rats were left 
      unligated (control group). The maternal general activity in an open field was 
      observed on gestational day (GD) 0, GD 4, and GD 14, and the maternal performance 
      was assessed on the second day after birth. The pups' play behavior was assessed 
      on postnatal day 30. The relative level of reelin was measured in the frontal 
      cortex by real-time PCR analysis. RESULTS: The results showed that, compared with 
      the control group, (1) the general activity in female rats with periodontitis was 
      decreased, (2) the maternal performance of these rats was not modified by 
      periodontitis, (3) the play behavior of pups from dams with periodontitis was 
      decreased, and (4) there were no differences in the frontal cortex reelin levels 
      of pups from dams with periodontitis. CONCLUSIONS: We conclude that pre- and 
      postnatal periodontitis induces maternal sickness behavior and reduces the pups' 
      play behavior without interference with frontal cortex reelin expression.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Pimentel, S P
AU  - Pimentel SP
AD  - Periodontology, Universidade Paulista, University of Sao Paulo, Sao Paulo, 
      Brazil.
FAU - Casati, M Z
AU  - Casati MZ
FAU - Cirano, F R
AU  - Cirano FR
FAU - Ribeiro, F V
AU  - Ribeiro FV
FAU - Casarin, R V
AU  - Casarin RV
FAU - Kirsten, T B
AU  - Kirsten TB
FAU - Chaves-Kirsten, G P
AU  - Chaves-Kirsten GP
FAU - Duarte, P M
AU  - Duarte PM
FAU - Bernardi, M M
AU  - Bernardi MM
LA  - eng
PT  - Journal Article
DEP - 20121114
PL  - Switzerland
TA  - Neuroimmunomodulation
JT  - Neuroimmunomodulation
JID - 9422763
RN  - 0 (Cell Adhesion Molecules, Neuronal)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Reelin Protein)
RN  - 0 (Reln protein, rat)
RN  - EC 3.4.21.- (Serine Endopeptidases)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Cell Adhesion Molecules, Neuronal/biosynthesis
MH  - Extracellular Matrix Proteins/biosynthesis
MH  - Female
MH  - Frontal Lobe/metabolism
MH  - Male
MH  - Maternal Behavior/*physiology
MH  - Nerve Tissue Proteins/biosynthesis
MH  - Periodontal Diseases/*complications
MH  - Pregnancy
MH  - *Pregnancy Complications
MH  - Rats
MH  - Rats, Wistar
MH  - Real-Time Polymerase Chain Reaction
MH  - Reelin Protein
MH  - Serine Endopeptidases/biosynthesis
MH  - *Social Behavior
EDAT- 2012/11/17 06:00
MHDA- 2013/07/19 06:00
CRDT- 2012/11/17 06:00
PHST- 2012/06/06 00:00 [received]
PHST- 2012/08/23 00:00 [accepted]
PHST- 2012/11/17 06:00 [entrez]
PHST- 2012/11/17 06:00 [pubmed]
PHST- 2013/07/19 06:00 [medline]
AID - 000342987 [pii]
AID - 10.1159/000342987 [doi]
PST - ppublish
SO  - Neuroimmunomodulation. 2013;20(1):29-38. doi: 10.1159/000342987. Epub 2012 Nov 
      14.