PMID- 23154578
OWN - NLM
STAT- MEDLINE
DCOM- 20130912
LR  - 20190608
IS  - 1880-3873 (Electronic)
IS  - 1340-3478 (Linking)
VI  - 20
IP  - 2
DP  - 2013
TI  - Effects of lutein supplement on serum inflammatory cytokines, ApoE and lipid 
      profiles in early atherosclerosis population.
PG  - 170-7
AB  - AIM: The purpose of this study was to determine the effects of lutein supplement 
      on serum cytokines, apoE and lipoprotein profiles in early atherosclerosis 
      population. METHODS: Early atherosclerosis patients (n= 65) were randomized to 
      receive placebo (A+P, n= 31) or 20 mg/d lutein (A+L, n= 34) for 3 months. 
      RESULTS: Serum lutein increased significantly compared to baseline after lutein 
      supplements in A+L group (p<0.001). Lutein supplements resulted in a significant 
      decrease in serum interleukin-6 (IL-6) and monocyte chemoattractant protein-1 
      (MCP-1) at 3 month in A+L group (p<0.05). Intragroup comparison revealed a 
      significant difference in the changes of serum MCP-1 between A+L and A+P groups 
      (p= 0.021). The serum low-density lipoprotein (LDL) and triglyceride (TG) 
      significantly decreased in A+L group (p<0.05). The changes in serum lutein were 
      negatively associated with those in serum LDL in A+L group (r=-0.384, p=0.043), 
      while no such relationship was observed in A+P group (r= 0.087, p= 0.685). 
      CONCLUSION: An increase in serum lutein after supplementation can reduce 
      inflammatory cytokines and regulate serum lipids, which may pay important roles 
      in early atherosclerosis.
FAU - Xu, Xian-Rong
AU  - Xu XR
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Haidian District, Beijing, PR, China.
FAU - Zou, Zhi-Yong
AU  - Zou ZY
FAU - Xiao, Xin
AU  - Xiao X
FAU - Huang, Yang-Mu
AU  - Huang YM
FAU - Wang, Xun
AU  - Wang X
FAU - Lin, Xiao-Ming
AU  - Lin XM
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121115
PL  - Japan
TA  - J Atheroscler Thromb
JT  - Journal of atherosclerosis and thrombosis
JID - 9506298
RN  - 0 (Apolipoproteins E)
RN  - 0 (Blood Glucose)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Cytokines)
RN  - 0 (Lipids)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Triglycerides)
RN  - X72A60C9MT (Lutein)
SB  - IM
MH  - Aged
MH  - Anthropometry
MH  - Apolipoproteins E/*blood
MH  - Atherosclerosis/*blood
MH  - Blood Glucose/analysis
MH  - Chemokine CCL2/blood
MH  - Cholesterol, LDL/blood
MH  - Cytokines/*blood
MH  - Diet
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Inflammation
MH  - Lipids/*blood
MH  - Lipoproteins, LDL/blood
MH  - Lutein/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Triglycerides/blood
EDAT- 2012/11/17 06:00
MHDA- 2013/09/13 06:00
CRDT- 2012/11/17 06:00
PHST- 2012/11/17 06:00 [entrez]
PHST- 2012/11/17 06:00 [pubmed]
PHST- 2013/09/13 06:00 [medline]
AID - DN/JST.JSTAGE/jat/14365 [pii]
AID - 10.5551/jat.14365 [doi]
PST - ppublish
SO  - J Atheroscler Thromb. 2013;20(2):170-7. doi: 10.5551/jat.14365. Epub 2012 Nov 15.