PMID- 23154721
OWN - NLM
STAT- MEDLINE
DCOM- 20130502
LR  - 20190606
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 51
IP  - 22
DP  - 2012
TI  - A puzzling case of phospho-soda-induced hypocalcemia in a patient with multiple 
      endocrine neoplasia type 1-associated primary hyperparathyroidism.
PG  - 3145-9
AB  - Although rare, symptomatic hypocalcemia may develop after the administration of 
      phospho-soda. We herein present the case of a patient with phospho-soda-induced 
      hypocalcemia who was surprisingly diagnosed with multiple endocrine neoplasia 
      type 1 (MEN1) caused by a heterozygous mutation in the MEN1 gene 
      (c628_631delACAG), thus resulting in a frameshift mutation (210ThrfsX224). In 
      addition to being the first report of phospho-soda-induced hypocalcemia in a 
      patient with MEN1-associated primary hyperparathyroidism, our report highlights 
      the complex nature of calcium balance in the human body and helps clinicians to 
      appreciate how confounding factors might affect the presentation of endocrine 
      disorders.
FAU - Ozveren, Ahmet
AU  - Ozveren A
AD  - Department of Internal Medicine, Tepecik Training and Research Hospital, Turkey.
FAU - Akinci, Baris
AU  - Akinci B
FAU - Makay, Ozer
AU  - Makay O
FAU - Sarsik, Banu
AU  - Sarsik B
FAU - Simsir, Ilgin Yildirim
AU  - Simsir IY
FAU - Berdeli, Afig
AU  - Berdeli A
FAU - Akyildiz, Mahir
AU  - Akyildiz M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20121115
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Laxatives)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Phosphates)
RN  - 0 (Proto-Oncogene Proteins)
RN  - SE337SVY37 (sodium phosphate)
SB  - IM
MH  - Adult
MH  - Base Sequence
MH  - DNA Mutational Analysis
MH  - Female
MH  - Frameshift Mutation
MH  - Humans
MH  - Hyperparathyroidism, Primary/*complications/pathology
MH  - Hypocalcemia/*chemically induced
MH  - Laxatives/adverse effects
MH  - Multiple Endocrine Neoplasia Type 1/*complications/diagnosis/genetics
MH  - Phosphates/adverse effects
MH  - Proto-Oncogene Proteins/genetics
EDAT- 2012/11/17 06:00
MHDA- 2013/05/03 06:00
CRDT- 2012/11/17 06:00
PHST- 2012/11/17 06:00 [entrez]
PHST- 2012/11/17 06:00 [pubmed]
PHST- 2013/05/03 06:00 [medline]
AID - DN/JST.JSTAGE/internalmedicine/51.7475 [pii]
AID - 10.2169/internalmedicine.51.7475 [doi]
PST - ppublish
SO  - Intern Med. 2012;51(22):3145-9. doi: 10.2169/internalmedicine.51.7475. Epub 2012 
      Nov 15.