PMID- 23154814
OWN - NLM
STAT- MEDLINE
DCOM- 20130529
LR  - 20221207
IS  - 1421-9778 (Electronic)
IS  - 1015-8987 (Linking)
VI  - 30
IP  - 6
DP  - 2012
TI  - Angiotensin II induces TSLP via an AT1 receptor/NF-KappaB pathway, promoting Th17 
      differentiation.
PG  - 1383-97
LID - 10.1159/000343327 [doi]
AB  - BACKGROUND: Adaptive immunity plays a critical role in atherosclerosis and 
      hypertension. T helper 17 (Th17) cells, as a new T-cell lineage, are involved in 
      cardiovascular diseases. Dendritic cells (DCs) are the professional 
      antigen-presenting cells with the pivotal role in orchestrating adaptive 
      immunity. Thymic stromal lymphopoietin (TSLP) can activate DCs and trigger 
      adaptive immune responses. What the role of TSLP in atherosclerosis and 
      hypertension has not been investigated. METHODS AND RESULTS: We measured the 
      expression of TSLP in primary rat vascular smooth muscle cells (VSMCs) exposed to 
      angiotensin II (Ang II) and evaluated the capacity of TSLP induced by Ang II to 
      induce the differentiation of Th17 Cells. We then sought to identify the involved 
      upstream regulatory mechanisms. We found that VSMCs express TSLP in response to 
      Ang II in an AT1 receptor/NF-KappaB manner. TSLP can induce the differentiation 
      of Th17 Cells by triggering DCs. CONCLUSION: Through DC activation, Ang 
      II-induced TSLP enhances Th17-driven immune response in atherosclerosis and 
      hypertension.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Zhao, Hui
AU  - Zhao H
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, Union Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      China.
FAU - Li, Ming
AU  - Li M
FAU - Wang, Lei
AU  - Wang L
FAU - Su, Yousu
AU  - Su Y
FAU - Fang, Hongcheng
AU  - Fang H
FAU - Lin, Jing
AU  - Lin J
FAU - Mohabeer, Nilesh
AU  - Mohabeer N
FAU - Li, Dazhu
AU  - Li D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121116
PL  - Germany
TA  - Cell Physiol Biochem
JT  - Cellular physiology and biochemistry : international journal of experimental 
      cellular physiology, biochemistry, and pharmacology
JID - 9113221
RN  - 0 (Cytokines)
RN  - 0 (NF-kappa B)
RN  - 0 (Receptor, Angiotensin, Type 1)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 11128-99-7 (Angiotensin II)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
RN  - 0 (TSLP protein, rat)
SB  - IM
MH  - Angiotensin II/*physiology
MH  - Animals
MH  - Aorta, Thoracic/pathology
MH  - Atherosclerosis/immunology
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Cytokines/genetics/*metabolism
MH  - Dendritic Cells/physiology
MH  - Gene Expression
MH  - Hypertension/immunology
MH  - Male
MH  - Muscle, Smooth, Vascular/pathology
MH  - Myocytes, Smooth Muscle
MH  - NF-kappa B/*metabolism
MH  - Primary Cell Culture
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Angiotensin, Type 1/*metabolism
MH  - Th17 Cells/immunology/*physiology
MH  - Transcriptional Activation
MH  - Tumor Necrosis Factor-alpha/physiology
MH  - Thymic Stromal Lymphopoietin
EDAT- 2012/11/17 06:00
MHDA- 2013/05/31 06:00
CRDT- 2012/11/17 06:00
PHST- 2012/10/19 00:00 [accepted]
PHST- 2012/11/17 06:00 [entrez]
PHST- 2012/11/17 06:00 [pubmed]
PHST- 2013/05/31 06:00 [medline]
AID - 000343327 [pii]
AID - 10.1159/000343327 [doi]
PST - ppublish
SO  - Cell Physiol Biochem. 2012;30(6):1383-97. doi: 10.1159/000343327. Epub 2012 Nov 
      16.