PMID- 23155179
OWN - NLM
STAT- MEDLINE
DCOM- 20130716
LR  - 20130204
IS  - 1522-1598 (Electronic)
IS  - 0022-3077 (Linking)
VI  - 109
IP  - 3
DP  - 2013 Feb
TI  - Relationship between electrophysiological signature and defined sensory modality 
      of trigeminal ganglion neurons in vivo.
PG  - 749-57
LID - 10.1152/jn.00693.2012 [doi]
AB  - The trigeminal ganglia (TG) innervate a heterogeneous set of highly sensitive and 
      exposed tissues. Weak, innocuous stimuli can evoke pain as a normal response in 
      some areas such as the cornea. This observation implies, however, the capability 
      of low-threshold mechanoreceptors, inducing pain in the normal condition. To 
      clarify this matter, the present study correlates the electrical signature (both 
      fiber conduction velocity and somatic electrical properties) with receptor field, 
      mechanical threshold, and temperature responsiveness of sensory afferents 
      innervating tissues with dissimilar sensitivity (skin vs. cornea) in the 
      trigeminal domain. Intracellular recordings were obtained in vivo from 148 
      neurons of the left TG of 62 mice. In 111 of these neurons, the peripheral 
      receptor field was successfully localized: 96 of them innervated the hairy skin, 
      while the remaining 15 innervated the cornea. The electrical signature was 
      defined and peripheral responses correlated with tissue target. No high threshold 
      neurons were found in the cornea. Moreover, the electrical signature of corneal 
      afferents resembles nociceptive neurons in the skin. TG skin afferents showed 
      similar membrane electrical signature and sensory modality as skin afferents from 
      dorsal root ganglion, although TG afferents exhibited a shorter duration of 
      afterhyperpolarization then those previously described in dorsal root ganglion. 
      These data suggest than new or different ways to classify and study TG sensory 
      neurons may be required.
FAU - Boada, M Danilo
AU  - Boada MD
AD  - Dept. of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC 
      27157-1009, USA. dboada@wakehealth.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121114
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - *Action Potentials
MH  - Animals
MH  - Cornea/innervation
MH  - Electric Stimulation
MH  - Mechanoreceptors/*physiology
MH  - Mice
MH  - Nerve Fibers/*physiology
MH  - Neural Conduction
MH  - Pain Threshold
MH  - Skin/innervation
MH  - Temperature
MH  - Trigeminal Nuclei/cytology/*physiology
EDAT- 2012/11/17 06:00
MHDA- 2013/07/17 06:00
CRDT- 2012/11/17 06:00
PHST- 2012/11/17 06:00 [entrez]
PHST- 2012/11/17 06:00 [pubmed]
PHST- 2013/07/17 06:00 [medline]
AID - jn.00693.2012 [pii]
AID - 10.1152/jn.00693.2012 [doi]
PST - ppublish
SO  - J Neurophysiol. 2013 Feb;109(3):749-57. doi: 10.1152/jn.00693.2012. Epub 2012 Nov 
      14.