PMID- 23155698
OWN - NLM
STAT- MEDLINE
DCOM- 20130115
LR  - 20220321
IS  - 0334-018X (Print)
IS  - 0334-018X (Linking)
VI  - 25
IP  - 7-8
DP  - 2012
TI  - Association analysis between endothelial function related factors and coronary 
      artery stenosis degree in coronary heart disease patients with type 2 diabetes 
      mellitus.
PG  - 711-6
AB  - OBJECTIVE: To investigate the relationship between soluble intercellular adhesion 
      molecule (sICAM-1), vascular endothelial cell adhesion molecule (VCAM-1), 
      monocytes chemotactic protein (MCP-1), von Willebrand factor (vWF), and coronary 
      artery stenoses degree in coronary heart disease (CHD) within type 2 diabetes 
      mellitus (T2DM) patients. METHODS: A total of 92 subjects were treated with 
      coronary angiography (CAG), including 62 subjects with CHD. The individuals were 
      divided into three groups, group A (32 patients with CHD and T2DM), group B (30 
      patients with CHD but no T2DM) and group C (30 patients with no CHD and T2DM). 
      All patients were treated with a Gensini coronary angiography check. The 
      correlations between sICAM-1, VCAM-1, MCP-1 and vWF in peripheral blood and 
      coronary artery stenosis degree were analyzed. RESULTS: The average score of 
      coronary artery stenosis degree was 30.75 +/-12.67 in group A, which was 
      significantly higher than group B (11.20 +/-7.51) and group C (2.40 +/- 1.23) (p 
      < 0.01). The mean levels of sICAM-1, VCAM-1, MCP-1 and vWF in serum showed that 
      group A was significantly higher than group B and group C (p < 0.01), and also 
      that group B was higher than group C. There were significant positive 
      correlations between the degree of coronary artery stenosis and the mean level of 
      sICAM-1, VCAM-1, MCP-1, vWF in group A (p < 0.01), but these were not shown in 
      group B and group C (p > 0.05). CONCLUSIONS: Association analysis shown that the 
      level of sICAM-1, VCAM-1, MCP-1 and vWF elevated in CHD with T2DM patients. 
      Vascular endothelial dysfunction could be caused to the coronary artery stenosis 
      pathophysiological process. Results from this study suggested that sICAM-1, 
      VCAM-1, MCP-1 and vWF may contribute to the occurrence and development of 
      vascular lesions in T2DM. These endothelial function related factors could be 
      acceptable as a prediction and testing index of vascular complications in T2DM.
FAU - Li, Quanmin
AU  - Li Q
AD  - Department of Endocrinology, General Hospital of the Second Artillery Force, The 
      People's Liberation Army, No.16 Xinwai street, Xicheng District, Beijing 100088, 
      People's Republic of China. quanmin_li@sina.com
FAU - Zhang, Zhifang
AU  - Zhang Z
FAU - Du, Ruiqin
AU  - Du R
FAU - Hu, Xiaoqiang
AU  - Hu X
FAU - Yan, Yan
AU  - Yan Y
FAU - Gao, Qing
AU  - Gao Q
FAU - Fan, Yanting
AU  - Fan Y
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - Germany
TA  - J Pediatr Endocrinol Metab
JT  - Journal of pediatric endocrinology & metabolism : JPEM
JID - 9508900
RN  - 0 (Cell Adhesion Molecules)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cell Adhesion Molecules/blood
MH  - Coronary Angiography
MH  - Coronary Disease/blood/diagnostic imaging/*etiology/physiopathology
MH  - Coronary Stenosis/blood/diagnostic imaging/*etiology/physiopathology
MH  - Coronary Vessels/diagnostic imaging/pathology/physiology
MH  - Diabetes Mellitus, Type 2/blood/*complications/diagnostic imaging/physiopathology
MH  - Diabetic Cardiomyopathies/blood/diagnostic imaging/*etiology/physiopathology
MH  - Disease Progression
MH  - Endothelium, Vascular/diagnostic imaging/metabolism/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Severity of Illness Index
EDAT- 2012/11/20 06:00
MHDA- 2013/01/16 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/01/16 06:00 [medline]
AID - 10.1515/jpem-2012-0159 [doi]
PST - ppublish
SO  - J Pediatr Endocrinol Metab. 2012;25(7-8):711-6. doi: 10.1515/jpem-2012-0159.