PMID- 23156850
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20221207
IS  - 0125-877X (Print)
IS  - 0125-877X (Linking)
VI  - 30
IP  - 3
DP  - 2012 Sep
TI  - Caesarean section and asthma in Malaysian children: a case-control study.
PG  - 204-8
AB  - BACKGROUND: Birth cohort studies in some countries have shown a link between 
      caesarean section and asthma. AIM: To determine if there is an association 
      between asthma and delivery via caesarean section in Malaysian children. METHOD: 
      This is a case-control study involving 156 children aged 3-15 years old, in a 
      tertiary hospital in Kuala Lumpur, Malaysia. Seventy-eight children with a 
      confirmed diagnosis of asthma and seventy-eight age-matched controls (no history 
      of asthma or wheezing) were enrolled. Demographic data including mode of delivery 
      and family history of allergic disorders was obtained. Total serum immunoglobulin 
      E (IgE) was measured and skin prick tests (SPT) to 6 common aeroallergens were 
      performed. RESULTS: The median age of the patients was 8 years old. One hundred 
      and three (66%) children were delivered via normal vaginal delivery, 8 (5.1%) via 
      assisted vaginal delivery and 45 children (28.9%) via caesarean section. Delivery 
      via caesarean section was not significantly associated with asthma (OR = 1.21 
      [95% CI 0.60-2.41], p = 0.596). Children delivered via caesarean section did not 
      have higher IgE levels nor were they more sensitized to aeroallergens. Multiple 
      logistic regression showed that asthma was significantly associated with a 
      positive family history of atopy (OR = 13.8 [95% CI 5.96, 32.1], p < 0.001). 
      Introduction of semi-solid food after 6 months old had a protective effect 
      against asthma (OR = 0.97 [95% CI 0.94, 0.99], p = 0.034). CONCLUSION: Childhood 
      asthma in Malaysian children was not associated with delivery by caesarean 
      section.
FAU - Nathan, Anna Marie
AU  - Nathan AM
AD  - Department of Paediatrics, University Malaya Medical Centre, Kuala Lumpur, 
      Malaysia. psr9900@hotmail.com
FAU - de Bruyne, Jessie
AU  - de Bruyne J
FAU - Khalid, Farah
AU  - Khalid F
FAU - Arumugam, Kulantheran
AU  - Arumugam K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - Asian Pac J Allergy Immunol
JT  - Asian Pacific journal of allergy and immunology
JID - 8402034
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/immunology
MH  - Asian People
MH  - Asthma/blood/*epidemiology/etiology/immunology
MH  - Case-Control Studies
MH  - Cesarean Section/adverse effects/*statistics & numerical data
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Malaysia/epidemiology
MH  - Pregnancy
MH  - Skin Tests/methods
MH  - Tertiary Care Centers
EDAT- 2012/11/20 06:00
MHDA- 2013/02/06 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
PST - ppublish
SO  - Asian Pac J Allergy Immunol. 2012 Sep;30(3):204-8.