PMID- 23157625
OWN - NLM
STAT- MEDLINE
DCOM- 20140117
LR  - 20220310
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 20
IP  - 3
DP  - 2013
TI  - Effects of antipsychotics on the BDNF in schizophrenia.
PG  - 345-50
AB  - Brain-derived neurotropic factor (BDNF) is involved in the development of the 
      brain, and likely influences the neuroplasticity in schizophrenia. BDNF is also 
      believed to interact with other neurotransmitter systems implicated in 
      schizophrenia, such as dopamine, glutamate, serotonin and GABA. Therefore, BDNF 
      is a candidate gene for schizophrenia. In past decades, the blood (serum or 
      plasma) BDNF protein levels and BDNF gene alleles and genotypes to the clinical 
      features of schizophrenia, such as age of onset, clinical subtypes, symptom 
      severity, and drug response, have been evaluated among different populations. 
      However, the results are still inconsistent. Further, different drugs have been 
      reported to have different effects on BDNF protein levels. A cross-sectional 
      survey revealed that serum BDNF levels in chronic schizophrenic patients treated 
      with clozapine exceeded those of patients treated with risperidone or with 
      typical antipsychotics. In recent times, BDNF epigenetic studies have also been 
      conducted in clinical studies of schizophrenia to address the question of why 
      patients with the same gene genotype and alleles have different clinical 
      presentations. In addition, the effects of different antipsychotic drugs on gene 
      methylation and protein acetylation have also been reported. In conclusion, more 
      data are needed regarding BDNF in the brain and in peripheral blood, including 
      protein levels, single nucleotide polymorphisms, epigenetic regulation, and 
      clinical data in order to understand the role of BDNF in schizophrenia.
FAU - Huang, T L
AU  - Huang TL
AD  - Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, 123, Ta-Pei Rd, 
      Niao-Sung, Kaohsiung 833, Taiwan, ROC. a540520@adm.cgmh.org.tw
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Acetylation
MH  - Animals
MH  - Antipsychotic Agents/chemistry/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/*antagonists & inhibitors/genetics/metabolism
MH  - Genotype
MH  - Humans
MH  - Methylation
MH  - Schizophrenia/*drug therapy/genetics/metabolism
EDAT- 2012/11/20 06:00
MHDA- 2014/01/18 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/07/15 00:00 [received]
PHST- 2012/08/31 00:00 [revised]
PHST- 2012/09/27 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2014/01/18 06:00 [medline]
AID - CMC-EPUB-20121113-4 [pii]
AID - 10.2174/092986713804870729 [doi]
PST - ppublish
SO  - Curr Med Chem. 2013;20(3):345-50. doi: 10.2174/092986713804870729.