PMID- 23158023
OWN - NLM
STAT- MEDLINE
DCOM- 20130531
LR  - 20211021
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 12
DP  - 2012 Nov 16
TI  - Antioxidant defense system and family environment in adolescents with family 
      history of psychosis.
PG  - 200
LID - 10.1186/1471-244X-12-200 [doi]
AB  - BACKGROUND: Our objective was to determine antioxidant defence activity in 
      healthy controls (HC) and healthy unaffected second-degree relatives of patients 
      with early onset psychosis (HC-FHP), and to assess its relationship with familiar 
      environment measured using the Family Environment Scale (FES). METHODS: We 
      included 82 HC and 14 HC-FHP aged between 9 and 17 years. Total antioxidant 
      status, lipid peroxidation, antioxidant enzyme activities and glutathione levels 
      were determined in blood samples. RESULTS: There was a significant decrease in 
      the total antioxidant level in the HC-FHP group compared with the HC group (OR = 
      2.94; p = 0.009), but no between-group differences in the Global Assessment of 
      Functioning (GAF) scale scores. For the FES, the HC-FHP group had significantly 
      higher scores in the cohesion (p = 0.007) and intellectual-cultural dimensions 
      (p=0.025). After adjusting for these two FES dimensions, total antioxidant status 
      remained significantly different between groups (OR = 10.86, p = 0.009). 
      CONCLUSIONS: Although causal relationships cannot be assumed, we can state that 
      family environment is not playing a role in inducing oxidative stress in these 
      healthy subjects. It could be hypothesized that families with affected relatives 
      protect themselves from psychosis with positive environmental factors such as 
      cohesion and intellectual-cultural activities.
FAU - Gonzalez-Pinto, Ana
AU  - Gonzalez-Pinto A
AD  - Stanley Institute International Mood Disorders Research Center, University of the 
      Basque Country, Centro de Investigacion Biomedica en Red de Salud Mental, 
      03-RC-003, Hospital Santiago, Vitoria, Spain. 
      monica.martinezcengotitabengoa@osakidetza.net
FAU - Martinez-Cengotitabengoa, Monica
AU  - Martinez-Cengotitabengoa M
FAU - Arango, Celso
AU  - Arango C
FAU - Baeza, Immaculada
AU  - Baeza I
FAU - Otero-Cuesta, Soraya
AU  - Otero-Cuesta S
FAU - Graell-Berna, Montserrat
AU  - Graell-Berna M
FAU - Soutullo, Cesar
AU  - Soutullo C
FAU - Leza, Juan Carlos
AU  - Leza JC
FAU - Mico, Juan Antonio
AU  - Mico JA
LA  - eng
PT  - Journal Article
DEP - 20121116
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
RN  - 0 (Antioxidants)
RN  - EC 1.11.1.15 (Peroxiredoxins)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Adolescent
MH  - Antioxidants/*physiology
MH  - Child
MH  - *Family Health
MH  - Female
MH  - Glutathione/blood
MH  - Humans
MH  - Lipid Peroxidation/physiology
MH  - Male
MH  - Peroxiredoxins/blood
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/metabolism/physiopathology/*psychology
MH  - Siblings/*psychology
PMC - PMC3539933
EDAT- 2012/11/20 06:00
MHDA- 2013/06/01 06:00
PMCR- 2012/11/16
CRDT- 2012/11/20 06:00
PHST- 2011/12/20 00:00 [received]
PHST- 2012/10/12 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
PHST- 2012/11/16 00:00 [pmc-release]
AID - 1471-244X-12-200 [pii]
AID - 10.1186/1471-244X-12-200 [doi]
PST - epublish
SO  - BMC Psychiatry. 2012 Nov 16;12:200. doi: 10.1186/1471-244X-12-200.