PMID- 23158876
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20211021
IS  - 1477-7819 (Electronic)
IS  - 1477-7819 (Linking)
VI  - 10
DP  - 2012 Nov 16
TI  - Laparoscopy-assisted versus open D2 radical gastrectomy for advanced gastric 
      cancer without serosal invasion: a case control study.
PG  - 248
LID - 10.1186/1477-7819-10-248 [doi]
AB  - BACKGROUND: The application of laparoscopic surgery for advanced gastric cancer 
      (AGC) remains questionable on account of technical difficulty of D2 
      lymphadenectomy, and there has been few large-scale follow-up results regarding 
      the oncological adequacy of laparoscopic surgery compared with that of open 
      surgeries for AGC. The aim of this study is to evaluate technical feasibility and 
      oncological efficacy of laparoscopy-assisted gastrectomy (LAG) for advanced 
      gastric cancer without serosal invasion. METHODS: From January 2008 to December 
      2012, 1114 patients with gastric cancer underwent D2 gastrectomy, including 
      336 T2 and T3 patients in term of depth of invasion. Of all 336 patients, 224 
      underwent LAG, while open gastrectomy (OG) performed on the other 112 patients. 
      The comparison was based on the clinicopathologic characteristics, surgical 
      outcome, and follow-up results. RESULTS: There are not significant differences in 
      clinicopathological characteristics between the two groups (P > 0.05). The 
      operation time and first ambulation time was similar in the two groups. However, 
      estimated blood loss, bowel function recovery time and duration of hospital stay 
      were significantly less in the LAG group. No significant difference in morbidity 
      and mortality was found between the LAG group and OG group (11.1% vs. 15.3%, 
      P = 0.266; 0.9% vs. 1.8%, P = 0.859). The mean number of resected lymph nodes 
      (LNS) between the LAG group and OG group was similar (30.6 +/- 10.1 vs. 30.3 +/- 8.6, 
      P = 0.786). Furthermore, the mean number of removed LNS in each station was not 
      significantly different in the distal gastrectomy and total gastrectomy 
      (P > 0.05). No statistical difference was seen in 1 year survival rate (91.5% vs. 
      89.8% P > 0.05) and the survival curve after surgery between the LAG group and OG 
      group. CONCLUSION: Laparoscopy-assisted D2 radical gastrectomy is feasible, 
      effective and has comparative oncological efficacy compared with open gastrectomy 
      for advanced gastric cancer without serosal invasion.
FAU - Chen, Qi-Yue
AU  - Chen QY
AD  - Department of Gastric Surgery, Fujian Medical University Union Hospital, No,29 
      Xinquan Road, Fuzhou, Fujian Province 350001, China.
FAU - Huang, Chang-Ming
AU  - Huang CM
FAU - Lin, Jian-Xian
AU  - Lin JX
FAU - Zheng, Chao-Hui
AU  - Zheng CH
FAU - Li, Ping
AU  - Li P
FAU - Xie, Jian-Wei
AU  - Xie JW
FAU - Wang, Jia-Bin
AU  - Wang JB
FAU - Lu, Jun
AU  - Lu J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20121116
PL  - England
TA  - World J Surg Oncol
JT  - World journal of surgical oncology
JID - 101170544
SB  - IM
MH  - Adenocarcinoma/mortality/pathology/*surgery
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Feasibility Studies
MH  - Female
MH  - Follow-Up Studies
MH  - *Gastrectomy
MH  - Humans
MH  - *Laparoscopy
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Serous Membrane/*pathology
MH  - Stomach Neoplasms/mortality/pathology/*surgery
MH  - Survival Rate
PMC - PMC3514136
EDAT- 2012/11/20 06:00
MHDA- 2013/05/25 06:00
PMCR- 2012/11/16
CRDT- 2012/11/20 06:00
PHST- 2012/09/14 00:00 [received]
PHST- 2012/11/04 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
PHST- 2012/11/16 00:00 [pmc-release]
AID - 1477-7819-10-248 [pii]
AID - 10.1186/1477-7819-10-248 [doi]
PST - epublish
SO  - World J Surg Oncol. 2012 Nov 16;10:248. doi: 10.1186/1477-7819-10-248.