PMID- 23159094
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20221115
IS  - 1873-2380 (Electronic)
IS  - 0021-9290 (Linking)
VI  - 46
IP  - 1
DP  - 2013 Jan 4
TI  - Inflow boundary conditions for image-based computational hemodynamics: impact of 
      idealized versus measured velocity profiles in the human aorta.
PG  - 102-9
LID - S0021-9290(12)00610-0 [pii]
LID - 10.1016/j.jbiomech.2012.10.012 [doi]
AB  - Here we analyse the influence of assumptions made on boundary conditions (BCs) 
      extracted from phase-contrast magnetic resonance imaging (PC-MRI) in vivo 
      measured flow data, applied on hemodynamic models of human aorta. This study aims 
      at investigating if the imposition of BCs based on defective information, even 
      when measured and specific-to-the-subject, might lead to misleading numerical 
      representations of the aortic hemodynamics. In detail, we focus on the influence 
      of assumptions regarding velocity profiles at the inlet section of the ascending 
      aorta, incorporating phase flow data within the computational model. The obtained 
      results are compared in terms of disturbed shear and helical bulk flow 
      structures, when the same measured flow rate is prescribed as inlet BC in terms 
      of 3D or 1D (axial) measured or idealized velocity profiles. Our findings clearly 
      indicate that: (1) the imposition of PC-MRI measured axial velocity profiles as 
      inflow BC may capture disturbed shear with sufficient accuracy, without the need 
      to prescribe (and measure) realistic fully 3D velocity profiles; (2) attention 
      should be put in setting idealized or PC-MRI measured axial velocity profiles at 
      the inlet boundaries of aortic computational models when bulk flow features are 
      investigated, because helical flow structures are markedly affected by the BC 
      prescribed at the inflow. We conclude that the plausibility of the assumption of 
      idealized velocity profiles as inlet BCs in personalized computational models can 
      lead to misleading representations of the aortic hemodynamics both in terms of 
      disturbed shear and bulk flow structures.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Morbiducci, Umberto
AU  - Morbiducci U
AD  - Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso 
      Duca degli Abruzzi, 24, 10129 Turin, Italy. umberto.morbiducci@polito.it
FAU - Ponzini, Raffaele
AU  - Ponzini R
FAU - Gallo, Diego
AU  - Gallo D
FAU - Bignardi, Cristina
AU  - Bignardi C
FAU - Rizzo, Giovanna
AU  - Rizzo G
LA  - eng
PT  - Journal Article
DEP - 20121113
PL  - United States
TA  - J Biomech
JT  - Journal of biomechanics
JID - 0157375
SB  - IM
MH  - Aorta/*physiology
MH  - Computer Simulation
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *Models, Cardiovascular
EDAT- 2012/11/20 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/05/30 00:00 [received]
PHST- 2012/10/08 00:00 [revised]
PHST- 2012/10/10 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - S0021-9290(12)00610-0 [pii]
AID - 10.1016/j.jbiomech.2012.10.012 [doi]
PST - ppublish
SO  - J Biomech. 2013 Jan 4;46(1):102-9. doi: 10.1016/j.jbiomech.2012.10.012. Epub 2012 
      Nov 13.