PMID- 23159196
OWN - NLM
STAT- MEDLINE
DCOM- 20130917
LR  - 20211021
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 206
IP  - 2-3
DP  - 2013 Apr 30
TI  - The course of cognitive functioning over six months in individuals at clinical 
      high risk for psychosis.
PG  - 195-9
LID - S0165-1781(12)00658-0 [pii]
LID - 10.1016/j.psychres.2012.10.013 [doi]
AB  - Cognitive impairment is common in psychosis and has recently been observed in 
      individuals at clinical high risk (CHR) of developing psychosis. The purpose of 
      this study was to characterize longitudinal change in cognition among CHR 
      individuals, and compare cognition of CHR individuals who later convert to 
      psychosis to that of CHR who do not convert. Participants were tested at baseline 
      and followed-up after six months using a comprehensive cognitive test battery. 
      Individuals who did not convert to psychosis either remained stable or 
      significantly improved in their cognitive performance. At baseline participants 
      who converted to psychosis compared to non-converters exhibited poorer 
      performance in several cognitive tests, suggesting that some cognitive impairment 
      is already present before conversion. Future longitudinal research should address 
      if further decline takes place during the prodrome or after conversion to 
      psychosis.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Barbato, Mariapaola
AU  - Barbato M
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Alberta, Canada.
FAU - Colijn, Mark A
AU  - Colijn MA
FAU - Keefe, Richard S E
AU  - Keefe RS
FAU - Perkins, Diana O
AU  - Perkins DO
FAU - Woods, Scott W
AU  - Woods SW
FAU - Hawkins, Keith A
AU  - Hawkins KA
FAU - Christensen, Bruce K
AU  - Christensen BK
FAU - Addington, Jean
AU  - Addington J
LA  - eng
GR  - U01MH066069-04/MH/NIMH NIH HHS/United States
GR  - U01 MH066160/MH/NIMH NIH HHS/United States
GR  - U01MH066160/MH/NIMH NIH HHS/United States
GR  - U01 MH066134/MH/NIMH NIH HHS/United States
GR  - U01MH06634-02/MH/NIMH NIH HHS/United States
GR  - K23 MH001905/MH/NIMH NIH HHS/United States
GR  - U01 MH066069/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121116
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adolescent
MH  - Child
MH  - *Cognition
MH  - Cognition Disorders/*psychology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Neuropsychological Tests
MH  - *Prodromal Symptoms
MH  - Prospective Studies
MH  - Psychotic Disorders/*psychology
MH  - Risk
MH  - Young Adult
PMC - PMC3600156
MID - NIHMS419384
EDAT- 2012/11/20 06:00
MHDA- 2013/09/18 06:00
PMCR- 2014/04/30
CRDT- 2012/11/20 06:00
PHST- 2012/08/27 00:00 [received]
PHST- 2012/10/22 00:00 [revised]
PHST- 2012/10/24 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/09/18 06:00 [medline]
PHST- 2014/04/30 00:00 [pmc-release]
AID - S0165-1781(12)00658-0 [pii]
AID - 10.1016/j.psychres.2012.10.013 [doi]
PST - ppublish
SO  - Psychiatry Res. 2013 Apr 30;206(2-3):195-9. doi: 10.1016/j.psychres.2012.10.013. 
      Epub 2012 Nov 16.