PMID- 23159796
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20220330
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 41
DP  - 2013 Mar 5
TI  - Decreased interhemispheric resting-state functional connectivity in 
      first-episode, drug-naive major depressive disorder.
PG  - 24-9
LID - S0278-5846(12)00285-0 [pii]
LID - 10.1016/j.pnpbp.2012.11.003 [doi]
AB  - BACKGROUND: Major depressive disorder (MDD) is shown to have structural and 
      functional abnormalities in specific brain areas and connections by recent 
      neuroimaging studies. However, little is known about the alterations of the 
      interhemispheric resting-state functional connectivity (FC) in patients with MDD. 
      In the present study, we used a newly developed voxel-mirrored homotopic 
      connectivity (VMHC) method to investigate the interhemispheric FC of the whole 
      brain in patients with MDD at rest. METHODS: Twenty-four first-episode, 
      drug-naive patients with MDD and 24 age-, gender-, and education-matched healthy 
      subjects underwent a resting-state functional magnetic resonance imaging (fMRI). 
      An automated VMHC approach was used to analyze the data. RESULTS: Patients with 
      MDD showed lower VMHC than healthy subjects in the medial prefrontal cortex 
      (MPFC) and the posterior cingulate cortex/precuneus (PCC/PCu), two core regions 
      within default mode network (DMN). Both left and right MPFC showed reduced FC 
      with the other frontal areas and with right anterior cingulate gyrus (ACC), while 
      PCC/PCu exhibited abnormal FC with the frontal areas and thalamus in patient 
      group. Significant positive correlation was observed between VMHC in MPFC and 
      persistent error response of Wisconsin Card Sorting Test (WCST-Pre) in patients. 
      Further ROC analysis revealed that VMHC in the MPFC and PCC/PCu could be used to 
      differentiate the patients from healthy subjects with relatively high sensitivity 
      and specificity. CONCLUSIONS: Our results suggest that decreased VMHC in brain 
      regions within DMN may underlie the pathogenesis of MDD.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Guo, Wenbin
AU  - Guo W
AD  - Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, 
      Nanning, Guangxi 530021, China. guowenbin76@163.com
FAU - Liu, Feng
AU  - Liu F
FAU - Dai, Yi
AU  - Dai Y
FAU - Jiang, Muliang
AU  - Jiang M
FAU - Zhang, Jian
AU  - Zhang J
FAU - Yu, Liuyu
AU  - Yu L
FAU - Long, Liling
AU  - Long L
FAU - Chen, Huafu
AU  - Chen H
FAU - Gao, Qing
AU  - Gao Q
FAU - Xiao, Changqing
AU  - Xiao C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121116
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cerebrum/*physiopathology
MH  - Depressive Disorder, Major/*diagnosis/*physiopathology/psychology
MH  - Feedback, Psychological/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Nerve Net/*physiopathology
MH  - Rest/*physiology/psychology
EDAT- 2012/11/20 06:00
MHDA- 2013/10/18 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/10/12 00:00 [received]
PHST- 2012/11/05 00:00 [revised]
PHST- 2012/11/06 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - S0278-5846(12)00285-0 [pii]
AID - 10.1016/j.pnpbp.2012.11.003 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2013 Mar 5;41:24-9. doi: 
      10.1016/j.pnpbp.2012.11.003. Epub 2012 Nov 16.