PMID- 23160217
OWN - NLM
STAT- MEDLINE
DCOM- 20130117
LR  - 20211021
IS  - 1529-2916 (Electronic)
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 13
IP  - 12
DP  - 2012 Dec
TI  - Re(de)fining the dendritic cell lineage.
PG  - 1145-54
LID - 10.1038/ni.2467 [doi]
AB  - Dendritic cells (DCs) are essential mediators of innate and adaptive immune 
      responses. Study of these critical cells has been complicated by their similarity 
      to other hematopoietic lineages, particularly monocytes and macrophages. Progress 
      has been made in three critical areas of DC biology: the characterization of 
      lineage-restricted progenitors in the bone marrow, the identification of 
      cytokines and transcription factors required during differentiation, and the 
      development of genetic tools for the visualization and depletion of DCs in vivo. 
      Collectively, these advances have clarified the nature of the DC lineage and have 
      provided novel insights into their function during health and disease.
FAU - Satpathy, Ansuman T
AU  - Satpathy AT
AD  - Department of Pathology and Immunology, Washington University in St. Louis, 
      School of Medicine, St. Louis, Missouri, USA.
FAU - Wu, Xiaodi
AU  - Wu X
FAU - Albring, Jorn C
AU  - Albring JC
FAU - Murphy, Kenneth M
AU  - Murphy KM
LA  - eng
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - P30 CA91842/CA/NCI NIH HHS/United States
GR  - P30 CA091842/CA/NCI NIH HHS/United States
GR  - AI076427-02/AI/NIAID NIH HHS/United States
GR  - R01 AI076427/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20121116
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Cytokines)
RN  - 0 (Transcription Factors)
SB  - IM
EIN - Nat Immunol. 2013 Apr;14(4):413
MH  - Bone Marrow Cells/cytology/immunology
MH  - *Cell Differentiation
MH  - *Cell Lineage
MH  - Cytokines/metabolism
MH  - Dendritic Cells/cytology/*immunology/metabolism
MH  - Humans
MH  - Macrophages/immunology
MH  - Monocytes/immunology
MH  - Stem Cells/cytology/metabolism
MH  - Transcription Factors/metabolism
PMC - PMC3644874
MID - NIHMS462597
COIS- The authors have no conflicting financial interests.
EDAT- 2012/11/20 06:00
MHDA- 2013/01/18 06:00
PMCR- 2013/12/01
CRDT- 2012/11/20 06:00
PHST- 2012/07/02 00:00 [received]
PHST- 2012/09/27 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/01/18 06:00 [medline]
PHST- 2013/12/01 00:00 [pmc-release]
AID - ni.2467 [pii]
AID - 10.1038/ni.2467 [doi]
PST - ppublish
SO  - Nat Immunol. 2012 Dec;13(12):1145-54. doi: 10.1038/ni.2467. Epub 2012 Nov 16.