PMID- 2316033
OWN - NLM
STAT- MEDLINE
DCOM- 19900424
LR  - 20061115
IS  - 0041-5782 (Print)
IS  - 0041-5782 (Linking)
VI  - 152
IP  - 12
DP  - 1990 Mar 19
TI  - [Heart transplantation in the era of cyclosporin].
PG  - 796-8
AB  - In a five-year period from February 1984, 76 orthotopic heart transplantations 
      were performed in the most extensive heart transplantation programme in the 
      Harvard Medical School in Boston, Massachusetts. The average age of the patients 
      was 43 years (range 14-61 years) and the sex distribution was 55 men/21 women. 
      Cardiomyopathy and ischaemic heart disease were the commonest indications for 
      transplantation. The actuarical survival was 84% after one year, 81% after two 
      years and 76% after five years. When the operative lethality is excluded, the 
      one-year survival was 91%, the two-year survival 88% and the five-year survival 
      82%. Six operative deaths occurred within the first 30 days and seven late 
      deaths, five of these from acute rejection and two as a result of transplant 
      atherosclerosis. No deaths were due to infection. Twelve patients developed 14 
      general surgical complications and laparotomy proved necessary in ten cases. One 
      of the patients died from haemorrhagic pancreatitis and the remainder had no 
      sequelae. An association was found between tissue type compatibility (human 
      leukocyte antigen (HLA)) between donor and recipient and the occurrence of 
      steroid resistant rejections.
FAU - Kjaergard, H K
AU  - Kjaergard HK
AD  - Thoraxkirurgisk afdeling RT, Rigshospitalet, Kobenhavn.
LA  - dan
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Hjertetransplantationer i ciklosporin-aeraen.
PL  - Denmark
TA  - Ugeskr Laeger
JT  - Ugeskrift for laeger
JID - 0141730
RN  - 0 (Cyclosporins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cyclosporins/*administration & dosage
MH  - Female
MH  - Graft Rejection/drug effects/immunology
MH  - Heart Transplantation/*mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
EDAT- 1990/03/19 00:00
MHDA- 1990/03/19 00:01
CRDT- 1990/03/19 00:00
PHST- 1990/03/19 00:00 [pubmed]
PHST- 1990/03/19 00:01 [medline]
PHST- 1990/03/19 00:00 [entrez]
PST - ppublish
SO  - Ugeskr Laeger. 1990 Mar 19;152(12):796-8.