PMID- 23160441
OWN - NLM
STAT- MEDLINE
DCOM- 20130521
LR  - 20121128
IS  - 1538-9235 (Electronic)
IS  - 1040-5488 (Linking)
VI  - 89
IP  - 12
DP  - 2012 Dec
TI  - The effect of daily lens replacement during overnight wear on ocular adverse 
      events.
PG  - 1674-81
LID - 10.1097/OPX.0b013e31827731ac [doi]
AB  - PURPOSE: Compared with daily disposable wear schedule, continuous wear (CW) or 
      extended wear of contact lenses has been associated with an increased risk of 
      developing an ocular infection. Proof-of-principle studies were conducted to 
      investigate the impact of daily replacement of lenses on the rate of contact 
      lens-related ocular adverse events (AEs) during 30-night CW. METHODS: A total of 
      215 subjects were dispensed with silicone hydrogel lenses on a 30-night CW 
      schedule but replaced lenses daily either each night before sleeping (n = 178 
      eyes) or each morning after waking (n = 252 eyes). Scheduled clinic visits were 
      conducted at 1 week and 1 month. Neophytes were required to complete 1 week of 
      daily wear before commencing CW. A historical control (n = 191 eyes) using the 
      same site, subject demographics, and visit schedule but monthly lens replacement 
      was used for AE rates. RESULTS: Logistic regression analysis showed a significant 
      reduction in mechanical AEs (0.8 vs 5.2%, p = 0.01) and overall AEs (inflammatory 
      and mechanical events) (4.0 vs 8.9%, p = 0.04) when lenses were replaced each 
      morning compared with being replaced monthly. Estimation of handling-related lens 
      contamination of unworn lenses in a subgroup of subjects showed isolation of 
      Staphylococcus aureus from the lenses of 35% of subjects, and 65% of subjects had 
      more than 1000 colony-forming units per lens of gram-positive bacterial 
      contamination. CONCLUSIONS: Morning lens replacement during CW reduced mechanical 
      and overall ocular AEs. Replacing lenses at night had no beneficial effects 
      perhaps because the benefit of a fresh lens at night might be partially negated 
      by contamination of the contact lens caused by lens handling before overnight eye 
      closure. Contact lens wearers on an extended wear or CW schedule should be 
      advised to minimize lens handling before sleep to reduce the risk of 
      complications.
FAU - Ozkan, Jerome
AU  - Ozkan J
AD  - Brien Holden Vision Institute, Sydney, New South Wales, Australia. 
      j.ozkan@brienholdenvision.org
FAU - Willcox, Mark D P
AU  - Willcox MD
FAU - de la Jara, Percy Lazon
AU  - de la Jara PL
FAU - Mandathara, Preeji S
AU  - Mandathara PS
FAU - Rathi, Varsha M
AU  - Rathi VM
FAU - Thomas, Varghese
AU  - Thomas V
FAU - Holden, Brien A
AU  - Holden BA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Optom Vis Sci
JT  - Optometry and vision science : official publication of the American Academy of 
      Optometry
JID - 8904931
SB  - IM
MH  - Colony Count, Microbial
MH  - Contact Lenses, Extended-Wear/*adverse effects/*microbiology
MH  - *Disposable Equipment
MH  - Eye Infections, Bacterial/*epidemiology/etiology/prevention & control
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - India/epidemiology
MH  - Male
MH  - Retrospective Studies
MH  - Staphylococcus aureus/*growth & development
MH  - Young Adult
EDAT- 2012/11/20 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 10.1097/OPX.0b013e31827731ac [doi]
PST - ppublish
SO  - Optom Vis Sci. 2012 Dec;89(12):1674-81. doi: 10.1097/OPX.0b013e31827731ac.