PMID- 23162376
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220129
IS  - 1388-0764 (Print)
IS  - 1572-896X (Electronic)
IS  - 1388-0764 (Linking)
VI  - 14
IP  - 6
DP  - 2012 Jun
TI  - Colloidal stability of polymeric nanoparticles in biological fluids.
PG  - 920
LID - 920
AB  - Estimating the colloidal stability of polymeric nanoparticles (NPs) in biological 
      environments is critical for designing optimal preparations and to clarify the 
      fate of these devices after administration. To characterize and quantify the 
      physical stability of nanodevices suitable for biomedical applications, spherical 
      NPs composed of poly-lactic acid (PLA) and poly-methyl-methacrylate (PMMA), in 
      the range 100-200 nm, were prepared. Their stability in salt solutions, 
      biological fluids, serum and tissue homogenates was analyzed by dynamic light 
      scattering (DLS). The PMMA NPs remained stable in all fluids, while PLA NPs 
      aggregated in gastric juice and spleen homogenate. The proposed stability test is 
      therefore useful to see in advance whether NPs might aggregate when administered 
      in vivo. To assess colloidal stability ex vivo as well, spectrophotofluorimetric 
      analysis was employed, giving comparable results to DLS.
FAU - Lazzari, Stefano
AU  - Lazzari S
AD  - Department of Chemistry and Applied Biosciences, Institute for Chemical and 
      Bioengineering, ETH Zurich, 8093 Zurich, Switzerland.
FAU - Moscatelli, Davide
AU  - Moscatelli D
FAU - Codari, Fabio
AU  - Codari F
FAU - Salmona, Mario
AU  - Salmona M
FAU - Morbidelli, Massimo
AU  - Morbidelli M
FAU - Diomede, Luisa
AU  - Diomede L
LA  - eng
GR  - GGP10120/TI_/Telethon/Italy
PT  - Journal Article
DEP - 20120606
PL  - Netherlands
TA  - J Nanopart Res
JT  - Journal of nanoparticle research : an interdisciplinary forum for nanoscale 
      science and technology
JID - 101088075
PMC - PMC3496558
EDAT- 2012/11/20 06:00
MHDA- 2012/11/20 06:01
PMCR- 2012/06/06
CRDT- 2012/11/20 06:00
PHST- 2011/08/03 00:00 [received]
PHST- 2012/05/10 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2012/11/20 06:01 [medline]
PHST- 2012/06/06 00:00 [pmc-release]
AID - 920 [pii]
AID - 10.1007/s11051-012-0920-7 [doi]
PST - ppublish
SO  - J Nanopart Res. 2012 Jun;14(6):920. doi: 10.1007/s11051-012-0920-7. Epub 2012 Jun 
      6.