PMID- 23162904
OWN - NLM
STAT- MEDLINE
DCOM- 20130926
LR  - 20121119
IS  - 0513-4870 (Print)
IS  - 0513-4870 (Linking)
VI  - 47
IP  - 8
DP  - 2012 Aug
TI  - [In vitro and in vivo evaluation of total flavones of Hippophae rhamnoides 
      self-microemulsifying drug delivery system].
PG  - 1055-62
AB  - The goal of the study is to evaluate the self-microemulsifying drug delivery 
      system (SMEDDS) which enhances the oral bioavailability of the poorly 
      water-soluble drug, total flavones of Hippophae rhamnoides (TFH). It is orally 
      administered for the protection of human cardiovascular system. 
      Self-microemulsifying time, particle size, polydispersity index (PDI), 
      morphological characterization, in vitro dispersity, stability, in situ 
      intestinal absorption and relative bioavailability were investigated in detail. 
      The TFH-SMEDDS rapidly formed fine oil-in-water microemulsions with 0.1 mol x 
      L(-1) hydrochloride solution, with average size of which was less than 40 nm, PDI 
      was below 0.2, and the particles of which were observed round-shaped under 
      transmission electron microscope. Almost 90% of TFH (expressed with quercetin) 
      was released from SMEDDS within 20 min, which was remarkably higher than that 
      from common capsules. The stability test showed the TFH-SMEDDS maintained stable 
      in 6 months under accelerated condition. In situ absorption study demonstrated 
      the absorption rate constant of TFH-SMEDDS (expressed with quercetin) was 
      significantly higher than that of TFH in ethanolic solution (P < 0.05). The 
      absorption of TFH from SMEDDS showed a 4.18-fold increase in relative 
      bioavailability (expressed with quercetin) compared with that of the suspension. 
      The results suggest that SMEDDS is a promising drug delivery system to increase 
      the oral bioavailability of TFH.
FAU - Li, Gui-ling
AU  - Li GL
AD  - Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Beijing 100050, China.
FAU - Fan, Ya-ting
AU  - Fan YT
FAU - Zhang, Yan-hui
AU  - Zhang YH
FAU - Li, Yan-fang
AU  - Li YF
FAU - Li, Xin-ru
AU  - Li XR
FAU - Liu, Yan
AU  - Liu Y
FAU - Li, Mei
AU  - Li M
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Yao Xue Xue Bao
JT  - Yao xue xue bao = Acta pharmaceutica Sinica
JID - 21710340R
RN  - 0 (Drug Carriers)
RN  - 0 (Emulsions)
RN  - 0 (Flavones)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Biological Availability
MH  - Drug Carriers
MH  - *Drug Delivery Systems
MH  - Emulsions
MH  - Flavones/administration & dosage/isolation & purification/*pharmacokinetics
MH  - Fruit/chemistry
MH  - Hippophae/*chemistry
MH  - *Intestinal Absorption
MH  - Male
MH  - Particle Size
MH  - Plant Leaves/chemistry
MH  - Plants, Medicinal/chemistry
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2012/11/20 06:00
MHDA- 2013/09/27 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/09/27 06:00 [medline]
PST - ppublish
SO  - Yao Xue Xue Bao. 2012 Aug;47(8):1055-62.