PMID- 23163503
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20220408
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
VI  - 66
IP  - 12
DP  - 2012 Dec
TI  - Symptoms in heart failure correlate poorly with objective haemodynamic 
      parameters.
PG  - 1224-9
LID - 10.1111/j.1742-1241.2012.03003.x [doi]
AB  - INTRODUCTION: Even though heart failure (HF) is a very common condition, 
      surprisingly little is known regarding association between patient's symptoms and 
      objective data. The purpose of this study was to evaluate for any correlations 
      between haemodynamic, echocardiographic and laboratory data of presenting 
      symptoms in HF patients. METHODS: This study is a retrospective analysis of the 
      limited access dataset from the Evaluation Study of Congestive Heart Failure and 
      Pulmonary Artery Catheterization Effectiveness (ESCAPE) trial provided by the 
      National Heart, Lung and Blood Institute. Symptoms including dyspnoea, 
      orthopnoea, fatigue and gastrointestinal (GI) discomfort were graded by their 
      severity from minimal (0) to maximal (3) on admission, at discharge, at 3 months 
      and at 6 months from the admission. Results of Minnesota Living with Heart 
      Failure (MLHF) score and assigned New York Heart Association (NYHA) functional 
      class were available at the same time points. RESULTS: A total of 433 patients 
      with decompensated HF and decreased systolic function (ejection fraction < 30%) 
      were included in this trial. Orthopnoea, dyspnoea and fatigue had weak 
      correlation with invasive pulmonary artery systolic and diastolic pressure and 
      negative correlation with serum creatinine, albumin, sodium, total bilirubin, 
      haemoglobin and haematocrit; fatigue showed positive correlation to pulmonary 
      artery pressures. Abdominal discomfort had no correlation to symptoms. There was 
      no correlation of symptoms, NYHA class, or MLHF scores with age, gender, peak 
      VO(2) on cardiopulmonary stress test, body mass index, either right or left 
      ventricular systolic function, B-type natriuretic peptide, cardiac output or 
      cardiac index, troponin level, velocity of tricuspid regurgitation and multiple 
      other factors predicting morbidity and mortality in HF. CONCLUSION: Overall, the 
      correlation between symptoms and objective parameters was weak. Because of low 
      magnitude of relationship between symptoms to objective parameters, it was 
      concluded that there are likely other factors determining the perception of 
      symptoms in HF patients.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Guglin, M
AU  - Guglin M
AD  - Department of Cardiology, University of South Florida, Tampa, FL 33606, USA. 
      mguglin@gmail.com
FAU - Patel, T
AU  - Patel T
FAU - Darbinyan, N
AU  - Darbinyan N
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/blood
MH  - Dyspnea/physiopathology
MH  - Echocardiography
MH  - Fatigue/etiology/physiopathology
MH  - Female
MH  - Heart Failure/etiology/*physiopathology
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
EDAT- 2012/11/21 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1111/j.1742-1241.2012.03003.x [doi]
PST - ppublish
SO  - Int J Clin Pract. 2012 Dec;66(12):1224-9. doi: 10.1111/j.1742-1241.2012.03003.x.