PMID- 23163570
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20221207
IS  - 1600-0463 (Electronic)
IS  - 0903-4641 (Linking)
VI  - 121
IP  - 7
DP  - 2013 Jul
TI  - Association of toll-like receptor 4 polymorphisms with type 2 diabetes mellitus.
PG  - 605-11
LID - 10.1111/apm.12027 [doi]
AB  - Toll-like receptor 4 (TLR4) plays important roles in modulating innate immunity. 
      Type 2 diabetes mellitus (T2DM) is a chronic and complex disease that is 
      characterized by impaired insulin resistance and dysregulated immune response. In 
      the current study, we investigated whether TLR4 polymorphisms were correlated 
      with susceptibility to T2DM in the Chinese population. Four TLR4 polymorphisms 
      (-2431T/C, Asp299Gly, Thr399Il3, and +3725G/C) were genotyped in 936 T2DM 
      patients and 978 healthy controls. Results showed that the prevalence of TLR4 
      +3725GC and CC genotypes was significantly decreased in T2DM cases than those in 
      controls [odds ratio (OR) = 0.68, 95% confidence interval (CI) = 0.55-0.84, p = 
      0.0003, and OR=0.46, 95% CI = 0.32-0.67, p = 3.71 x 10(-5) , respectively). Also, 
      the frequency of TLR4 +3725C allele was significantly lower in T2DM patients (p = 
      2.50 x 10(-8) ). The -2431T/C did not reveal any significant differences between 
      cases and controls. We did not detect Asp299Gly and Thr399Il3 polymorphisms in 
      our study group. Stratification analysis of the clinical features in the patients 
      demonstrated that frequency of +3725CC genotype was lower in patients older than 
      50 years old (p = 0.047). In conclusion, these results indicate that TLR4 
      +3725G/C polymorphism may be a novel protective factor against T2DM in the 
      Chinese population.
CI  - (c) 2012 APMIS. Published by John Wiley & Sons Ltd.
FAU - Cai, Huayin
AU  - Cai H
AD  - Department of Emergency Rescue, The Second Affiliated Hospital of Fujian Medical 
      University, Quanzhou, China.
FAU - Cai, Junfeng
AU  - Cai J
FAU - Tao, Geng
AU  - Tao G
LA  - eng
PT  - Journal Article
DEP - 20121120
PL  - Denmark
TA  - APMIS
JT  - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
JID - 8803400
RN  - 0 (Blood Glucose)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 4)
RN  - 2ZD004190S (Threonine)
RN  - 7006-34-0 (Asparagine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Asparagine/genetics/metabolism
MH  - Blood Glucose
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Confidence Intervals
MH  - Diabetes Mellitus, Type 2/*genetics/metabolism
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - Threonine/genetics/metabolism
MH  - Toll-Like Receptor 4/*genetics
MH  - Waist-Hip Ratio
EDAT- 2012/11/21 06:00
MHDA- 2013/08/27 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/08/02 00:00 [received]
PHST- 2012/10/10 00:00 [accepted]
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - 10.1111/apm.12027 [doi]
PST - ppublish
SO  - APMIS. 2013 Jul;121(7):605-11. doi: 10.1111/apm.12027. Epub 2012 Nov 20.