PMID- 23164066
OWN - NLM
STAT- MEDLINE
DCOM- 20130405
LR  - 20220330
IS  - 1524-4725 (Electronic)
IS  - 1076-0512 (Linking)
VI  - 39
IP  - 2
DP  - 2013 Feb
TI  - Systematic review of clinical trials of small- and large-gel-particle hyaluronic 
      acid injectable fillers for aesthetic soft tissue augmentation.
PG  - 205-31
LID - 10.1111/dsu.12036 [doi]
AB  - BACKGROUND: Hyaluronic acid (HA) is the most frequently injected filler for soft 
      tissue augmentation in the United States. OBJECTIVE: To systematically review 
      published evidence for aesthetic use of small- and large-gel-particle HA. METHODS 
      AND MATERIALS: Clinical data on anatomic area, level of evidence, patient 
      population, trial design, endpoints, efficacy, and safety were extracted from 
      PubMed. RESULTS: Fifty-three primary clinical reports were analyzed. The 
      highest-quality efficacy evidence was for the nasolabial folds (NLFs), with 10 
      randomized, blind, split-face, comparative trials. Several randomized, blind 
      trials supported treatment of the glabella, lips, and hands. Lower-level evidence 
      (from studies with nonrandomized, open-label, or retrospective designs) was 
      recorded for the nasojugal folds (tear troughs), upper eyelids, nose, 
      infraorbital hollows, oral commissures, marionette lines, perioral rhytides, 
      temples, and cheeks. Common adverse events (AEs) across anatomic areas were pain, 
      bruising, swelling, and redness. Serious AEs were uncommon (8 events in 8 
      patients of 4,605 total patients) and were considered to be unrelated (7 events) 
      or probably unrelated (1 event) to treatment. CONCLUSION: The efficacy and safety 
      of small- and large-gel-particle HA are well established for NLFs; evidence for 
      the glabella, lips, and hands is more limited. Preliminary reports in other 
      anatomic regions suggest efficacy without major complications.
CI  - (c) 2012 by the American Society for Dermatologic Surgery, Inc. Published by Wiley 
      Periodicals, Inc.
FAU - Cohen, Joel L
AU  - Cohen JL
AD  - AboutSkin Dermatology and DermSurgery, Englewood, Colorado 80113, USA. 
      jcohenderm@yahoo.com
FAU - Dayan, Steven H
AU  - Dayan SH
FAU - Brandt, Fredric S
AU  - Brandt FS
FAU - Nelson, Diane B
AU  - Nelson DB
FAU - Axford-Gatley, Robert A
AU  - Axford-Gatley RA
FAU - Theisen, Michael J
AU  - Theisen MJ
FAU - Narins, Rhoda S
AU  - Narins RS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20121116
PL  - United States
TA  - Dermatol Surg
JT  - Dermatologic surgery : official publication for American Society for Dermatologic 
      Surgery [et al.]
JID - 9504371
RN  - 0 (Gels)
RN  - 0 (Viscosupplements)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - *Clinical Trials as Topic
MH  - *Cosmetic Techniques
MH  - Gels
MH  - Humans
MH  - Hyaluronic Acid/*administration & dosage/chemistry
MH  - Particle Size
MH  - Skin Aging/*drug effects
MH  - Treatment Outcome
MH  - Viscosupplements/*administration & dosage/chemistry
EDAT- 2012/11/21 06:00
MHDA- 2013/04/06 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/04/06 06:00 [medline]
AID - 10.1111/dsu.12036 [doi]
PST - ppublish
SO  - Dermatol Surg. 2013 Feb;39(2):205-31. doi: 10.1111/dsu.12036. Epub 2012 Nov 16.