PMID- 2316433
OWN - NLM
STAT- MEDLINE
DCOM- 19900426
LR  - 20191029
IS  - 0379-0363 (Print)
IS  - 0379-0363 (Linking)
VI  - 29
DP  - 1990
TI  - Time pattern of allergic reactions to drugs.
PG  - 39-58
AB  - Generalized, allergic reactions to drugs show time patterns different from those 
      based on pharmacological concepts. We distinguish three types of reactions: acute 
      reactions (reaction time (RT): 0-60 minutes), subacute reactions (RT: 1-24 hours) 
      and reactions of the latent type (RT: 1 day to several weeks). In this study, 
      allergic reactions in the strict sense are supplemented by reactions considered 
      to be based on intolerance or idiosyncrasy to aspirin, pyrazolones, paracetamol, 
      NSAIDs, quinidine, iodine-containing contrast media and some as yet not 
      understood reactions to local anaesthetics. Out of a total of 23,935 drug 
      monitoring patients with 32,317 hospitalizations in the clinical divisions of 
      internal medicine at three Swiss hospitals during the 1974-1987 period, 951 
      patients with 1,040 probably or definitely drug-related events of the selected 
      type were recorded. Ultimately, 287 patients with 310 adverse drug reactions 
      (ADRs) fulfilled our selection criteria and were classified into six groups of 
      syndromes (Table 1). (Of the reactions described as maculopapular rash, 
      unspecified rash and special exanthema, only the 159 reactions from the 1985-1987 
      period out of a total of 889 reactions of this type observed during the whole 
      study period were included in our secondary evaluation.) The total number of 310 
      reactions (100%) showed the following RT distribution: 36 (11.6%) were of the 
      acute type, 13 (4.2%) of the latent type, 12 (3.9%) could be interpreted as two 
      distinct possible types of reaction to different drugs, and for 3 (1.0%) 
      reactions, the type of reaction was indeterminable. The majority of reactions, 
      246 (79.4%), were of the subacute type starting within 24 hours of the last drug 
      exposure. Among the 36 reactions of the acute type, 7 events of acute severe 
      dyspnoea were observed which seemed to be as life-threatening as anaphylactic or 
      anaphylactoid shock. These hospital-epidemiological data are of interest for 
      focusing basic research and developing further principles of drug safety.
FAU - Hoigne, R
AU  - Hoigne R
FAU - Jaeger, M D
AU  - Jaeger MD
FAU - Wymann, R
AU  - Wymann R
FAU - Egli, A
AU  - Egli A
FAU - Muller, U
AU  - Muller U
FAU - Hess, T
AU  - Hess T
FAU - Galeazzi, R
AU  - Galeazzi R
FAU - Maibach, R
AU  - Maibach R
FAU - Kunzi, U P
AU  - Kunzi UP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Agents Actions Suppl
JT  - Agents and actions. Supplements
JID - 7801014
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Anti-Bacterial Agents/adverse effects
MH  - Drug Hypersensitivity/*physiopathology
MH  - Humans
MH  - Hypersensitivity, Delayed/*chemically induced/epidemiology
MH  - Hypersensitivity, Immediate/*chemically induced/epidemiology
MH  - Switzerland
MH  - Time Factors
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1007/978-3-0348-7292-8_5 [doi]
PST - ppublish
SO  - Agents Actions Suppl. 1990;29:39-58. doi: 10.1007/978-3-0348-7292-8_5.