PMID- 23164419
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20190608
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 78
IP  - 6
DP  - 2012 Dec
TI  - Reversible left ventricular dysfunction and acute kidney injury in a patient with 
      nonamyloid light chain deposition disease.
PG  - 501-5
AB  - Non-amyloid light chain deposition disease (LCDD) is a rare entity that most 
      commonly presents as proteinuria and/or renal dysfunction. We report on a patient 
      who initially presented with acutely decompensated heart failure and subsequently 
      developed nephrotic range proteinuria with attendant advanced renal dysfunction. 
      The diagnosis of LCCD was made on renal biopsy.She was treated with five cycles 
      of bortezomib and dexamethasone followed by cyclophosphamide priming for 
      peripheral blood stem cell (PBSC) mobilization and auto logousstem cell 
      transplant (ASCT). Four years later, she remains in very good partial response 
      (VGPR) with a left ventricular ejection fraction (LVEF) of 58% and serum 
      creatinine of 1.1 mg/dl. This observation supports the approach of aggressive 
      management of patients with LCDD who have multiple organ failure.
FAU - Wadhwa, Nand K
AU  - Wadhwa NK
AD  - Divisions of Nephrology, Cardiology, Oncology, Department of Medicine and 
      Department of Pathology, School of Medicine, State University of New York at 
      Stony Brook, NY 11794, USA. nand.wadhwa@sbumed.org
FAU - Kamra, Amit
AU  - Kamra A
FAU - Skopicki, Hal A
AU  - Skopicki HA
FAU - Richard, Shambavi
AU  - Richard S
FAU - Miller, Frederick
AU  - Miller F
FAU - Nord, Edward P
AU  - Nord EP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Acute Kidney Injury/*etiology
MH  - Female
MH  - Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Immunoglobulin Light Chains/*metabolism
MH  - Middle Aged
MH  - Paraproteinemias/*complications
MH  - Transplantation, Autologous
MH  - Ventricular Dysfunction, Left/*etiology
EDAT- 2012/11/21 06:00
MHDA- 2013/04/24 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - 9312 [pii]
AID - 10.5414/cn107347 [doi]
PST - ppublish
SO  - Clin Nephrol. 2012 Dec;78(6):501-5. doi: 10.5414/cn107347.