PMID- 23164835
OWN - NLM
STAT- MEDLINE
DCOM- 20130805
LR  - 20130204
IS  - 1878-1519 (Electronic)
IS  - 1569-9048 (Linking)
VI  - 185
IP  - 3
DP  - 2013 Feb 1
TI  - Bone marrow mononuclear cell therapy in experimental allergic asthma: 
      intratracheal versus intravenous administration.
PG  - 615-24
LID - S1569-9048(12)00335-7 [pii]
LID - 10.1016/j.resp.2012.11.005 [doi]
AB  - We hypothesized that the route of administration would impact the beneficial 
      effects of bone marrow-derived mononuclear cell (BMDMC) therapy on the 
      remodelling process of asthma. C57BL/6 mice were randomly assigned to two main 
      groups. In the OVA group, mice were sensitized and challenged with ovalbumin, 
      while the control group received saline using the same protocol. Twenty-four 
      hours before the first challenge, control and OVA animals were further randomized 
      into three subgroups to receive saline (SAL), BMDMCs intravenously (2x10(6)), or 
      BMDMCs intratracheally (2x10(6)). The following changes were induced by BMDMC 
      therapy in OVA mice regardless of administration route: reduction in resistive 
      and viscoelastic pressures, static elastance, eosinophil infiltration, collagen 
      fibre content in airways and lung parenchyma; and reduction in the levels of 
      interleukin (IL)-4, IL-13, transforming growth factor-beta and vascular endothelial 
      growth factor. In conclusion, BMDMC modulated inflammatory and remodelling 
      processes regardless of administration route in this experimental model of 
      allergic asthma.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Abreu, Soraia C
AU  - Abreu SC
AD  - Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of 
      Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
FAU - Antunes, Mariana A
AU  - Antunes MA
FAU - Maron-Gutierrez, Tatiana
AU  - Maron-Gutierrez T
FAU - Cruz, Fernanda F
AU  - Cruz FF
FAU - Ornellas, Debora S
AU  - Ornellas DS
FAU - Silva, Adriana L
AU  - Silva AL
FAU - Diaz, Bruno L
AU  - Diaz BL
FAU - Ab'Saber, Alexandre M
AU  - Ab'Saber AM
FAU - Capelozzi, Vera L
AU  - Capelozzi VL
FAU - Xisto, Debora G
AU  - Xisto DG
FAU - Morales, Marcelo M
AU  - Morales MM
FAU - Rocco, Patricia R M
AU  - Rocco PR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121117
PL  - Netherlands
TA  - Respir Physiol Neurobiol
JT  - Respiratory physiology & neurobiology
JID - 101140022
SB  - IM
MH  - Administration, Intravenous
MH  - Animals
MH  - Asthma/*pathology/*therapy
MH  - Bone Marrow Transplantation/*methods
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Leukocytes, Mononuclear/*transplantation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Microscopy, Confocal
MH  - Microscopy, Electron, Transmission
EDAT- 2012/11/21 06:00
MHDA- 2013/08/06 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/03/06 00:00 [received]
PHST- 2012/11/08 00:00 [revised]
PHST- 2012/11/09 00:00 [accepted]
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/08/06 06:00 [medline]
AID - S1569-9048(12)00335-7 [pii]
AID - 10.1016/j.resp.2012.11.005 [doi]
PST - ppublish
SO  - Respir Physiol Neurobiol. 2013 Feb 1;185(3):615-24. doi: 
      10.1016/j.resp.2012.11.005. Epub 2012 Nov 17.