PMID- 23165408
OWN - NLM
STAT- MEDLINE
DCOM- 20130509
LR  - 20220409
IS  - 1558-2035 (Electronic)
IS  - 1558-2027 (Linking)
VI  - 13
IP  - 12
DP  - 2012 Dec
TI  - Prevalence and clinical characteristics of adult patients with congenital heart 
      disease in Tuscany.
PG  - 805-9
LID - 10.2459/JCM.0b013e3283569b3a [doi]
AB  - AIMS: The clinical features of the adult population with congenital heart disease 
      (CHD) are still not well characterized, particularly in the subset with more 
      severe lesions. We report the data collected in the National Association of 
      Hospital Cardiologists Toscana grown-up CHD (GUCH) registry over its first 
      8-month enrolment period. METHODS: The Registry included consecutive patients 
      aged more than 16 years with a documented diagnosis of CHD, enrolled in seven 
      different Tuscan hospitals using a web-based electronic form. Severe CHD was 
      defined as cyanotic CHD, or acyanotic lesion with significant haemodynamic impact 
      requiring surgical and/or percutaneous correction. RESULTS: Between November 2009 
      and June 2010 a total of 1641 patients (mean age 41.8 +/- 19.3 years, 52.2% women) 
      were enrolled. Atrial septal defect was the most common lesion, accounting for 
      more than one-third of cases. Atrial and ventricular septal defects together 
      accounted for about half of all CHDs. Nearly one-third of patients had New York 
      Heart Association (NYHA) class 2 or more. A history of recurrent arrhythmias was 
      reported in 15% of cases, and 12% of patients were on oral anticoagulants at the 
      time of enrolment. The prevalence of pulmonary hypertension was 6%, and the 
      prevalence of Eisenmenger syndrome was 1.2%. Severe CHD was present in 42% of 
      patients. Younger age, higher NYHA class, male sex, and the need for oral 
      anticoagulants were the only independent predictors of severe CHD. CONCLUSION: 
      Information about the clinical characteristics and the CHD type distribution of a 
      sample of Tuscan GUCH population was provided. Severe CHD accounts for about 40% 
      of all CHDs in this population. CHD severity is associated with younger age, male 
      gender, worse NYHA class, and need for oral anticoagulation.
FAU - Favilli, Silvia
AU  - Favilli S
AD  - UOC Cardiologia, AOU A.Meyer, Firenze, Italy. s.favilli@meyer.it
FAU - Santoro, Gennaro
AU  - Santoro G
FAU - Ballo, Piercarlo
AU  - Ballo P
FAU - Arcangeli, Chiara
AU  - Arcangeli C
FAU - Bovenzi, Francesco M
AU  - Bovenzi FM
FAU - Chiappa, Enrico
AU  - Chiappa E
FAU - Conti, Umberto
AU  - Conti U
FAU - Monopoli, Anna
AU  - Monopoli A
FAU - Murzi, Bruno
AU  - Murzi B
FAU - Rosini, Costanza
AU  - Rosini C
FAU - Zuppiroli, Alfredo
AU  - Zuppiroli A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cardiovasc Med (Hagerstown)
JT  - Journal of cardiovascular medicine (Hagerstown, Md.)
JID - 101259752
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Administration, Oral
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Anticoagulants/administration & dosage
MH  - Female
MH  - Heart Defects, Congenital/diagnosis/*epidemiology/therapy
MH  - Humans
MH  - Italy/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prognosis
MH  - Registries
MH  - Residence Characteristics
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Time Factors
MH  - Young Adult
EDAT- 2012/11/21 06:00
MHDA- 2013/05/10 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/05/10 06:00 [medline]
AID - 01244665-201212000-00005 [pii]
AID - 10.2459/JCM.0b013e3283569b3a [doi]
PST - ppublish
SO  - J Cardiovasc Med (Hagerstown). 2012 Dec;13(12):805-9. doi: 
      10.2459/JCM.0b013e3283569b3a.