PMID- 23165507
OWN - NLM
STAT- MEDLINE
DCOM- 20131203
LR  - 20151119
IS  - 1476-5624 (Electronic)
IS  - 1362-4393 (Linking)
VI  - 51
IP  - 3
DP  - 2013 Mar
TI  - Falls in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis 
      (HAM/TSP).
PG  - 222-5
LID - 10.1038/sc.2012.134 [doi]
AB  - STUDY DESIGN: Cross-sectional study. OBJECTIVES: To determine the prevalence of 
      falls in human T-cell lymphotropic virus type I (HTLV-I)-associated 
      myelopathy/tropical spastic paraparesis (HAM/TSP) patients and possible factors 
      associated to their occurrence. SETTING: Instituto de Pesquisa Clinica Evandro 
      Chagas, Fundacao Oswaldo Cruz (FIOCRUZ) - Brazil. METHODS: Thirty-six HAM/TSP 
      patients able to walk at least 20 m were assessed by a questionnaire. Data 
      regarding gender, age, duration of disease (DD), HTLV-I proviral load (HPL), 
      frequency of physical activity (FCA), use of walking aids, functional ambulation 
      level, the number of falls and associated injuries in the last year were 
      reviewed. Multiple correspondence analysis was used to group characteristics of 
      this sample according to the fall occurrence. RESULTS: The prevalence of falls 
      was 63.9% and we observed injuries in 47.8% of the cases. Four groups were 
      identified in the descriptive analysis. One group was formed by faller 
      individuals, men <60 years, independent ambulation, FCA>/=3 times per week and HPL 
      <6.6 copies per 100 cells (group B). The other one comprised non-faller patients, 
      women >/=60 years, restricted ambulation, DD >/=7 years, use of orthosis, FCA 0-1 
      time per week and HPL >/=6.6 copies per 100 cells (group D). The others two groups 
      comprised individuals that did not use orthosis (group A) and those that FCA was 
      two times per week and DD <7 years (group C). CONCLUSION: Falls occur in roughly 
      two-thirds of ambulatory HAM/TSP patients and are associated with significant 
      morbidity. Further studies with a larger number of patients are necessarily to 
      identify risk factors in order to elaborate specific programs to prevent falls in 
      this population.
FAU - Facchinetti, L D
AU  - Facchinetti LD
AD  - Section of Rehabilitation, Instituto de Pesquisa Clinica Evandro Chagas/Fundacao 
      Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
FAU - Araujo, A Q
AU  - Araujo AQ
FAU - Chequer, G L
AU  - Chequer GL
FAU - de Azevedo, M F
AU  - de Azevedo MF
FAU - de Oliveira, R V C
AU  - de Oliveira RV
FAU - Lima, M A
AU  - Lima MA
LA  - eng
PT  - Journal Article
DEP - 20121120
PL  - England
TA  - Spinal Cord
JT  - Spinal cord
JID - 9609749
SB  - IM
MH  - *Accidental Falls
MH  - Adult
MH  - Aged
MH  - Brazil/epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - HTLV-I Infections/diagnosis/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Paraparesis, Tropical Spastic/*diagnosis/*epidemiology
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2012/11/21 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - sc2012134 [pii]
AID - 10.1038/sc.2012.134 [doi]
PST - ppublish
SO  - Spinal Cord. 2013 Mar;51(3):222-5. doi: 10.1038/sc.2012.134. Epub 2012 Nov 20.