PMID- 23166367
OWN - NLM
STAT- MEDLINE
DCOM- 20130802
LR  - 20130808
IS  - 1741-7899 (Electronic)
IS  - 1470-1626 (Linking)
VI  - 145
IP  - 2
DP  - 2013 Feb
TI  - The roles of glial cell line-derived neurotrophic factor, brain-derived 
      neurotrophic factor and nerve growth factor during the final stage of 
      folliculogenesis: a focus on oocyte maturation.
PG  - R43-54
LID - 10.1530/REP-12-0219 [doi]
AB  - Neurotrophic factors were first identified to promote the growth, survival or 
      differentiation of neurons and have also been associated with the early stages of 
      ovarian folliculogenesis. More recently, their effects on the final stage of 
      follicular development, including oocyte maturation and early embryonic 
      development, have been reported. Glial cell line-derived neurotrophic factor 
      (GDNF), brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), 
      which are expressed in numerous peripheral tissues outside of the CNS, most 
      notably the ovary, are now known to stimulate oocyte maturation in various 
      species, also enhancing developmental competence. The mechanisms that underlie 
      their actions in antral follicles, as well as the targets ultimately controlled 
      by these factors, are beginning to emerge. GDNF, BDNF and NGF, alone or in 
      combination, could be added to the media currently utilized for in vitro oocyte 
      maturation, thereby potentially increasing the production and/or quality of early 
      embryos.
FAU - Linher-Melville, Katja
AU  - Linher-Melville K
AD  - Department of Pathology and Molecular Medicine, McMaster University, Hamilton, 
      Ontario, L8S4L8 Canada.
FAU - Li, Julang
AU  - Li J
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130124
PL  - England
TA  - Reproduction
JT  - Reproduction (Cambridge, England)
JID - 100966036
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism/pharmacology/*physiology
MH  - Cells, Cultured
MH  - Female
MH  - Glial Cell Line-Derived Neurotrophic Factor/metabolism/pharmacology/*physiology
MH  - Humans
MH  - In Vitro Oocyte Maturation Techniques/methods
MH  - Nerve Growth Factor/metabolism/pharmacology/*physiology
MH  - Oocytes/drug effects/metabolism/physiology
MH  - Oogenesis/drug effects/*physiology
MH  - Ovarian Follicle/drug effects/metabolism/*physiology
EDAT- 2012/11/21 06:00
MHDA- 2013/08/03 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/08/03 06:00 [medline]
AID - REP-12-0219 [pii]
AID - 10.1530/REP-12-0219 [doi]
PST - epublish
SO  - Reproduction. 2013 Jan 24;145(2):R43-54. doi: 10.1530/REP-12-0219. Print 2013 
      Feb.