PMID- 23167185
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20181202
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 26
IP  - 15
DP  - 2012 Aug
TI  - [Analysis on expression of survivin and PTEN in vocal cords polyps, papilloma of 
      larynx and laryngeal squamous cell carcinoma].
PG  - 704-7
AB  - OBJECTIVE: Through exploring the differentiation on positive expressing rates 
      between oncogene survivin and tumor-suppressor gene PTEN (phosphatase and tensin 
      homolog deleted on chromosome ten) on vocal cord polyps (VCP), adult type 
      laryngeal papilloma (ALP), and laryngeal squamous cell carcinoma (LSCC), to 
      reveal the mechanism in cancellation of human laryngeal squamous cells, from 
      benign proliferative lesion, benign tumor to malignant tumor in larynx. METHOD: 
      After picking out 18 cases of VCP, 10 cases of ALP, and 18 cases of LSCC for 
      immunohistochemical process of Survivin and PTEN with two continuous section 
      preparations, the differentiations of positive expression rates of Survivin and 
      PTEN in the same human laryngeal squamous cells areas among three diseases were 
      compared. RESULT: The positive expressing rates of survivin and PTEN in VCP were 
      obviously more lower than in ALP and LSCC (P < 0.05), which showed no obvious 
      difference between each other(P > 0.05). The positive expressing rates of 
      survivin were always higher than PTEN in VCP, ALP and LSCC evidently (P < 0.05). 
      CONCLUSION: PTEN, expressing for competition purpose, shows a subordinative 
      relationship with Survivin. Although they have opposite functions in determine 
      whether the cancellation of laryngeal squamous cells take place or not, Survivin 
      is always playing the leading role and making predominant impact on development 
      of benign proliferative lesion, benign and malignant tumor in larynx.
FAU - Guo, Qiangzhong
AU  - Guo Q
AD  - Department of Otolaryngology, Second Affiliated Hospital of Guangzhou University 
      of Traditional Chinese Medicine, 510120, Guangzhou, China.
FAU - Li, Yunying
AU  - Li Y
LA  - chi
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Survivin)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (PTEN protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins/*metabolism
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Middle Aged
MH  - PTEN Phosphohydrolase/*metabolism
MH  - Polyps/metabolism/pathology
MH  - Survivin
MH  - Vocal Cords/*pathology
EDAT- 2012/11/22 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/11/22 06:00
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Aug;26(15):704-7.