PMID- 23167362
OWN - NLM
STAT- MEDLINE
DCOM- 20130610
LR  - 20190606
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 13
IP  - 9
DP  - 2012
TI  - Lack of association of glutathione S-transferase M3 gene polymorphism with the 
      susceptibility of lung cancer.
PG  - 4465-8
AB  - OBJECTIVE: The conclusions of published reports on the relationship between the 
      glutathione S-transferase M3 (GSTM3) A/B gene polymorphism and the risk of lung 
      cancer are still debated. This meta-analysis was performed to evaluate the 
      association between GSTM3 and the risk of lung cancer. METHODS: Association 
      investigations were identified from PubMed, Embase, and Cochrane Library, and 
      eligible studies were included and synthesized using a meta-analysis method. 
      RESULTS: Eight reports were included into this meta-analysis for the association 
      of GSTM3 A/B gene polymorphism and lung cancer susceptibility, covering 1,854 
      patients with lung cancer and 1,926 controls. No association between the GSTM3 
      A/B gene polymorphism and lung cancer was found in this meta-analysis (B allele: 
      OR = 1.25, 95% CI: 0.89-1.76, P = 0.20; BB genotype: OR = 1.53, 95% CI: 
      0.71-3.32, P = 0.28; AA genotype: OR = 0.85, 95% CI: 0.59-1.23, P = 0.39). 
      CONCLUSIONS: The GSTM3 A/B gene polymorphism is not associated with lung cancer 
      susceptibility. However, more studies on the relationship between GSTM3 A/B gene 
      polymorphism and the risk of lung cancer should be performed in the future.
FAU - Feng, Xu
AU  - Feng X
AD  - Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi 
      Medical University, NanNing, China.
FAU - Dong, Chun-Qiang
AU  - Dong CQ
FAU - Shi, Jun-Jie
AU  - Shi JJ
FAU - Zhou, Hua-Fu
AU  - Zhou HF
FAU - He, Wei
AU  - He W
FAU - Zheng, Bao-Shi
AU  - Zheng BS
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Hod protein, mouse)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Isoenzymes)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - EC 2.5.1.18 (glutathione transferase M3-3)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Confidence Intervals
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Glutathione Transferase/*genetics
MH  - Homeodomain Proteins
MH  - Humans
MH  - Isoenzymes/genetics
MH  - Lung Neoplasms/*genetics
MH  - Polymorphism, Genetic
EDAT- 2012/11/22 06:00
MHDA- 2013/06/12 06:00
CRDT- 2012/11/22 06:00
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - 10.7314/apjcp.2012.13.9.4465 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2012;13(9):4465-8. doi: 10.7314/apjcp.2012.13.9.4465.