PMID- 23168845
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20151119
IS  - 1319-2442 (Print)
IS  - 1319-2442 (Linking)
VI  - 23
IP  - 6
DP  - 2012 Nov
TI  - Laparoscopic donor nephrectomy versus open donor nephrectomy: recipient's 
      perspective.
PG  - 1175-80
LID - 10.4103/1319-2442.103556 [doi]
AB  - Effects of laparoscopic donor nephrectomy (LDN) on graft function, especially 
      early post-transplant, have been controversial. To assess and compare early and 
      late graft function in kidneys procured by open and laparoscopic methods, a 
      retrospective observational study was carried out on 37 recipients-donors who 
      underwent LDN after introduction of this technique in February 2007 at our 
      center, a tertiary care nephrology referral center. Demographic, immunological 
      and intraoperative variables as well as immunosuppressive protocols and number of 
      human leukocyte antigen (HLA) mismatches were noted. Early graft function was 
      assessed by serum creatinine on Days two, five, seven, 14 and 28 and at the time 
      of discharge. Serum creatinine values at three months and at one year 
      post-transplant were considered as the surrogates of late graft function. Data 
      obtained were compared with the data from 33 randomly selected kidney transplants 
      performed after January 2000 by the same surgical team, in whom open donor 
      nephrectomy was used. Pearson's chi square test, Student's t test and 
      Mann-Whitney U test were used for statistical analysis. Early graft function 
      (serum creatinine on Day five 2.15 mg/dL vs 1.49 mg/dL, P = 0.027) was poorer in 
      the LDN group. Late graft function as assessed by serum creatinine at three 
      months (1.45 mg/dL vs 1.31 mg/dL, P = 0.335) and one year (1.56 mg/dL vs 1.34 
      mg/dL, P = 0.275) was equivalent in the two groups. Episodes of early acute graft 
      dysfunction due to acute tubular necrosis were significantly higher in the LDN 
      group (37.8% vs 12.1%, Z score 2.457, P = 0.014). Warm ischemia time was 
      significantly prolonged in the LDN group (255 s vs 132.5 s, P = 0.002). LDN is 
      associated with slower recovery of graft function and higher incidence of early 
      acute graft dysfunction due to acute tubular necrosis. Late graft function at one 
      year is however comparable.
FAU - Jamale, Tukaram E
AU  - Jamale TE
AD  - Division of Kidney Transplantation, Deparment of Nephrology, Seth GS Medical 
      College, Parel, Mumbai, India. tukaramjamale@yahoo.co.in
FAU - Hase, Niwrutti K
AU  - Hase NK
FAU - Iqbal, Anwar M
AU  - Iqbal AM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi J Kidney Dis Transpl
JT  - Saudi journal of kidney diseases and transplantation : an official publication of 
      the Saudi Center for Organ Transplantation, Saudi Arabia
JID - 9436968
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
RN  - 0 (Immunosuppressive Agents)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Chi-Square Distribution
MH  - Creatinine/blood
MH  - Female
MH  - HLA Antigens/immunology
MH  - Histocompatibility
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - India
MH  - Kidney Transplantation/adverse effects/*methods
MH  - Kidney Tubular Necrosis, Acute/blood/etiology
MH  - *Laparoscopy/adverse effects
MH  - Male
MH  - Middle Aged
MH  - Nephrectomy/adverse effects/*methods
MH  - Patient Safety
MH  - Primary Graft Dysfunction/blood/etiology
MH  - Recovery of Function
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Tertiary Care Centers
MH  - Time Factors
MH  - Treatment Outcome
MH  - Warm Ischemia/adverse effects
EDAT- 2012/11/22 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/11/22 06:00
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - SaudiJKidneyDisTranspl_2012_23_6_1175_103556 [pii]
AID - 10.4103/1319-2442.103556 [doi]
PST - ppublish
SO  - Saudi J Kidney Dis Transpl. 2012 Nov;23(6):1175-80. doi: 
      10.4103/1319-2442.103556.