PMID- 2316911
OWN - NLM
STAT- MEDLINE
DCOM- 19900419
LR  - 20131121
IS  - 0002-9645 (Print)
IS  - 0002-9645 (Linking)
VI  - 51
IP  - 3
DP  - 1990 Mar
TI  - Pharmacokinetics of phenylbutazone given intravenously or orally in mature 
      Holstein bulls.
PG  - 367-70
AB  - Six mature Holstein bulls were each given 10 mg of phenylbutazone (PBZ)/kg of 
      body weight, PO. Of the 6 bulls, 3 were given 10 mg of PBZ/kg by rapid IV 
      administration 4 weeks later. Plasma concentration-vs-time data were analyzed, 
      using nonlinear regression modeling (sum of exponential functions). The harmonic 
      mean of the biologic half-life of PBZ was 62.6 +/- 12.9 hours after oral 
      administration and 61.6 +/- 7.2 hours after IV administration. The mean residence 
      time was 94.61 +/- 8.44 hours and 90.49 +/- 8.93 hours for oral and IV 
      administration, respectively. The mean total body clearance was 0.0015 +/- 0.0003 
      L/h/kg, with the mean apparent volume of distribution 0.134 +/- 0.021 L/kg. Mean 
      bioavailability was 73 +/- 2% after oral administration. Phenylbutazone was 
      adequately absorbed from the gastrointestinal tract in bulls. The apparent volume 
      of distribution was small, indicating that PBZ distributed mainly into plasma and 
      extracellular fluid. The total body clearance was also small, which accounted for 
      the long half-life of PBZ in bulls.
FAU - Williams, R J
AU  - Williams RJ
AD  - Department of Clinical Sciences, College of Veterinary Medicine and Biomedical 
      Sciences, Colorado State University, Fort Collins 80523.
FAU - Smith, J A
AU  - Smith JA
FAU - Boudinot, F D
AU  - Boudinot FD
FAU - Knight, A P
AU  - Knight AP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Vet Res
JT  - American journal of veterinary research
JID - 0375011
RN  - GN5P7K3T8S (Phenylbutazone)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Biological Availability
MH  - Cattle/*metabolism
MH  - Half-Life
MH  - Injections, Intravenous/veterinary
MH  - Male
MH  - Metabolic Clearance Rate
MH  - Phenylbutazone/administration & dosage/blood/*pharmacokinetics
MH  - Time Factors
EDAT- 1990/03/01 00:00
MHDA- 1990/03/01 00:01
CRDT- 1990/03/01 00:00
PHST- 1990/03/01 00:00 [pubmed]
PHST- 1990/03/01 00:01 [medline]
PHST- 1990/03/01 00:00 [entrez]
PST - ppublish
SO  - Am J Vet Res. 1990 Mar;51(3):367-70.