PMID- 23170046
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20211021
IS  - 1880-5086 (Electronic)
IS  - 0912-0009 (Print)
IS  - 0912-0009 (Linking)
VI  - 51
IP  - 3
DP  - 2012 Nov
TI  - Strategies for peptic ulcer healing after 1 week proton pump inhibitor-based 
      triple Helicobacter pylori eradication therapy in Japanese patients: differences 
      of gastric ulcers and duodenal ulcers.
PG  - 189-95
LID - 10.3164/jcbn.12-15 [doi]
AB  - Helicobacter pylori (H. pylori) eradication therapy alone is insufficient to 
      ensure healing of large ulcers with H. pylori-positive gastric ulcer (GU). The 
      question of what is the optimum antiulcer treatment following H. pylori 
      eradication therapy has not been fully elucidated. Furthermore, the ulcer healing 
      effects of eradication therapy itself with H. pylori-positive duodenal ulcer (DU) 
      have not been investigated. In GU study, the eradication therapy + proton pump 
      inhibitor (PPI) group (group A) were administered eradication therapy followed by 
      7 weeks of a PPI, and the eradication therapy + gastroprotective drug (GP) group 
      (group B) eradication therapy followed by 7 weeks of a GP. In DU study, the 
      eradication therapy + PPI group (group C) were administered eradication therapy 
      followed by 5 weeks of a PPI, and the eradication therapy only group (group D) 
      was eradication therapy alone. In GU study, healing rates for ulcer of >/=15 mm in 
      diameter were significant greater in the group A. In DU study, high healing rates 
      were seen both the group C and D. In conclusion, a PPI could significantly heal 
      GU than a GP after eradication therapy in GU. Meanwhile, the eradication alone is 
      sufficient for DU.
FAU - Takeuchi, Toshihisa
AU  - Takeuchi T
AD  - 2nd Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-machi, 
      Takatsuki-City, Osaka 569-8686, Japan.
FAU - Umegaki, Eiji
AU  - Umegaki E
FAU - Takeuchi, Nozomi
AU  - Takeuchi N
FAU - Yoda, Yukiko
AU  - Yoda Y
FAU - Kojima, Yuichi
AU  - Kojima Y
FAU - Tokioka, Satoshi
AU  - Tokioka S
FAU - Higuchi, Kazuhide
AU  - Higuchi K
CN  - OMC G&H research group
LA  - eng
PT  - Journal Article
DEP - 20120608
PL  - Japan
TA  - J Clin Biochem Nutr
JT  - Journal of clinical biochemistry and nutrition
JID - 8700907
PMC - PMC3491243
OTO - NOTNLM
OT  - Helicobacter pylori eradication therapy
OT  - gastroprotective drug
OT  - peptic ulcer
OT  - proton pump inhibitor
OT  - ulcer healing
EDAT- 2012/11/22 06:00
MHDA- 2012/11/22 06:01
PMCR- 2012/11/01
CRDT- 2012/11/22 06:00
PHST- 2012/02/02 00:00 [received]
PHST- 2012/02/21 00:00 [accepted]
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2012/11/22 06:01 [medline]
PHST- 2012/11/01 00:00 [pmc-release]
AID - jcbn12-15 [pii]
AID - 10.3164/jcbn.12-15 [doi]
PST - ppublish
SO  - J Clin Biochem Nutr. 2012 Nov;51(3):189-95. doi: 10.3164/jcbn.12-15. Epub 2012 
      Jun 8.