PMID- 23170235
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121122
LR  - 20211021
IS  - 2162-3279 (Electronic)
IS  - 2162-3279 (Print)
VI  - 2
IP  - 6
DP  - 2012 Nov
TI  - BDNF Val66Met polymorphism interacts with sex to influence bimanual motor control 
      in healthy humans.
PG  - 726-31
LID - 10.1002/brb3.83 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) plays a critical role in brain 
      development. A common single nucleotide polymorphism in the gene encoding BDNF 
      (rs6265, Val66Met) affects BDNF release and has been associated with altered 
      learning and memory performance, and with structural changes in brain morphology 
      and corpus callosum integrity. BDNF Val66Met has more recently been shown to 
      influence motor learning and performance. Some of the BDNF effects seem to be 
      modulated by an individual's sex, but currently the relationship between BDNF and 
      sex in the motor domain remains elusive. Here, we investigate the relationship 
      between BDNF Val66Met genotype and an individual's sex in the motor system. 
      Seventy-six healthy, previously genotyped, individuals performed a task in which 
      the participant drew lines at different angles of varying difficulty. Subjects 
      controlled the horizontal and vertical movement of the line on a computer screen 
      by rotating two cylinders. We used this bimanual motor control task to measure 
      contributions from both current motor function and the pre-existing 
      interhemispheric connectivity. We report that BDNF genotype interacts with sex to 
      influence the motor performance of healthy participants in this bimanual motor 
      control task. We further report that the BDNF genotype by sex interaction was 
      present in the more difficult trials only, which is in line with earlier findings 
      that genetic effects may become apparent only when a system is challenged. Our 
      results emphasize the importance of taking sex into account when investigating 
      the role of BDNF genotype in the motor system.
FAU - Smolders, Ruud
AU  - Smolders R
AD  - Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen 
      Nijmegen, The Netherlands ; Department of Psychiatry, Academic Medical Center, 
      University of Amsterdam Amsterdam, The Netherlands.
FAU - Rijpkema, Mark
AU  - Rijpkema M
FAU - Franke, Barbara
AU  - Franke B
FAU - Fernandez, Guillen
AU  - Fernandez G
LA  - eng
PT  - Journal Article
DEP - 20120904
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
PMC - PMC3500459
OTO - NOTNLM
OT  - BDNF
OT  - Preilowski's task
OT  - Val66Met
OT  - bimanual
OT  - genetics
OT  - motor
OT  - rs6265
OT  - single nucleotide polymorphism
EDAT- 2012/11/22 06:00
MHDA- 2012/11/22 06:01
PMCR- 2012/11/01
CRDT- 2012/11/22 06:00
PHST- 2011/12/21 00:00 [received]
PHST- 2012/06/15 00:00 [revised]
PHST- 2012/06/17 00:00 [accepted]
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2012/11/22 06:01 [medline]
PHST- 2012/11/01 00:00 [pmc-release]
AID - 10.1002/brb3.83 [doi]
PST - ppublish
SO  - Brain Behav. 2012 Nov;2(6):726-31. doi: 10.1002/brb3.83. Epub 2012 Sep 4.