PMID- 2317085
OWN - NLM
STAT- MEDLINE
DCOM- 19900416
LR  - 20161219
IS  - 0003-9896 (Print)
IS  - 0003-9896 (Linking)
VI  - 45
IP  - 1
DP  - 1990 Jan-Feb
TI  - Elevated serum IgE, eosinophilia, and lung function in rubber workers.
PG  - 15-9
AB  - We previously reported an outbreak of acute respiratory illness associated with 
      eosinophilia in a group of rubber workers who performed a thermoinjection process 
      in which synthetic rubber was heated and then injected onto metal molds. This 
      study was conducted to determine if persistent respiratory health effects were 
      associated with this work area and to explore the possible allergic etiology of 
      this syndrome. A survey was performed 1 mo after a major improvement in area 
      ventilation and consisted of baseline, cross-shift, and cross-week spirometry; 
      diffusing capacity; serum immunoglobulin E (IgE), total eosinophil count; and 
      skin patch testing. Baseline lung function, cross-shift, and cross-week 
      spirometry were not significantly worse in the exposed group as compared to the 
      control group. However, either eosinophilia (greater than 450/mm3) or elevated 
      serum IgE (greater than 470 ng/ml) were present in 44% of exposed workers vs. 11% 
      of the control group (p = .003). Nine months later, neither eosinophilia nor 
      elevated IgE were associated with employment in this work area. We conclude that 
      employment in the thermoinjection process was associated with eosinophilia and 
      elevated IgE, which suggests sensitization to one of the components of the 
      rubber, although no effect on pulmonary function could be demonstrated.
FAU - Bascom, R
AU  - Bascom R
AD  - Department of Environmental Health Sciences, Johns Hopkins Medical Institutions, 
      Baltimore, Maryland.
FAU - Baser, M E
AU  - Baser ME
FAU - Thomas, R J
AU  - Thomas RJ
FAU - Fisher, J F
AU  - Fisher JF
FAU - Yang, W N
AU  - Yang WN
FAU - Baker, J H
AU  - Baker JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Environ Health
JT  - Archives of environmental health
JID - 0212627
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-04-6 (Rubber)
SB  - IM
MH  - Adult
MH  - *Chemical Industry
MH  - Eosinophilia/*blood
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Hypersensitivity, Delayed/physiopathology
MH  - Immunoglobulin E/*analysis
MH  - Lung/*physiopathology
MH  - Lung Volume Measurements
MH  - Male
MH  - Middle Aged
MH  - Occupational Diseases/blood/physiopathology
MH  - Patch Tests
MH  - Respiratory Tract Diseases/blood/physiopathology
MH  - *Rubber
MH  - Spirometry
MH  - Vital Capacity
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1080/00039896.1990.9935918 [doi]
PST - ppublish
SO  - Arch Environ Health. 1990 Jan-Feb;45(1):15-9. doi: 10.1080/00039896.1990.9935918.