PMID- 23171011
OWN - NLM
STAT- MEDLINE
DCOM- 20130507
LR  - 20210331
IS  - 1365-4632 (Electronic)
IS  - 0011-9059 (Linking)
VI  - 51
IP  - 12
DP  - 2012 Dec
TI  - Positivity for HLA DR1 is associated with basal cell carcinoma in renal 
      transplant patients in southern Brazil.
PG  - 1448-53
LID - 10.1111/j.1365-4632.2011.05282.x [doi]
AB  - BACKGROUND: Renal transplant patients have a higher incidence of non-melanoma 
      skin cancer (NMSC). Previous studies hypothesized that human leukocyte antigen 
      (HLA), especially types DR1, DR4, and DR7, may influence the incidence of these 
      tumors. This study investigates the association between NMSC and the presence of 
      HLA DR1, DR4, and DR7 in renal transplant patients in southern Brazil. METHODS: 
      In a historical cohort study, 1032 patients who underwent renal transplantation 
      during the period from January 1993 to December 2006 were examined to identify 
      occurrences of NMSC and HLA status prior to transplant. RESULTS: Of the 1032 
      patients examined, 59 (5.71%) developed NMSC (squamous cell carcinoma [SCC]: 
      2.42%; basal cell carcinoma [BCC]: 1.74%; both: 1.55%). The presence of HLA DR1 
      was associated with a higher probability of developing any NMSC and particularly 
      with developing BCC (P < 0.05). There was no statistically significant 
      association between the presence of HLA DR4 or DR7 and the occurrence of NMSC in 
      this sample. CONCLUSIONS: HLA DR1 appears to be associated with the development 
      of BCC, as well as with the higher number of NMSC lesions in renal transplant 
      patients. This study supports the trend to associate the DR1 allele with BCC and 
      not with SCC.
CI  - (c) 2012 The International Society of Dermatology.
FAU - de Carvalho, Andre V E
AU  - de Carvalho AV
AD  - Department of Dermatology, Complexo Hospitalar Santa Casa de Porto Alegre, Santa 
      Casa Hospital Complex, Porto Alegre, Brazil. avecarvalho@me.com
FAU - Bonamigo, Renan R
AU  - Bonamigo RR
FAU - da Silva, Cristina M
AU  - da Silva CM
FAU - Pinto, Angela C De Zorzi
AU  - Pinto AC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 0 (HLA-DR1 Antigen)
SB  - IM
MH  - Adult
MH  - Brazil/epidemiology
MH  - Carcinoma, Basal Cell/epidemiology/*genetics
MH  - Carcinoma, Squamous Cell/epidemiology/genetics
MH  - Cohort Studies
MH  - Female
MH  - Genetic Predisposition to Disease/epidemiology/genetics
MH  - HLA-DR1 Antigen/*genetics
MH  - Humans
MH  - Incidence
MH  - *Kidney Transplantation/statistics & numerical data
MH  - Male
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Skin Neoplasms/epidemiology/*genetics
EDAT- 2012/11/23 06:00
MHDA- 2013/05/08 06:00
CRDT- 2012/11/23 06:00
PHST- 2012/11/23 06:00 [entrez]
PHST- 2012/11/23 06:00 [pubmed]
PHST- 2013/05/08 06:00 [medline]
AID - 10.1111/j.1365-4632.2011.05282.x [doi]
PST - ppublish
SO  - Int J Dermatol. 2012 Dec;51(12):1448-53. doi: 10.1111/j.1365-4632.2011.05282.x.