PMID- 23171839
OWN - NLM
STAT- MEDLINE
DCOM- 20130207
LR  - 20121122
IS  - 2105-0678 (Print)
IS  - 2105-0678 (Linking)
VI  - 206
IP  - 3
DP  - 2012
TI  - [Dysfunction of the blood-brain barrier during ischaemia: a therapeutic concern].
PG  - 161-76
LID - 10.1051/jbio/2012020 [doi]
AB  - Since it was discovered and its brain-protective role characterized, the 
      blood-brain barrier (BBB), through the permeability-restricting action of the 
      brain capillary endothelial cells, has been representing a hurdle for 95% of new 
      medical compounds targeting the central nervous system. Recently, a BBB 
      dysfunction is being found in an increasing number of pathologies such as brain 
      ischaemic stroke, whose only therapy consists in a pharmacological thrombolysis 
      limited to a small percentage of the admitted patients, because of the toxical 
      effects of thrombolytics. And since the clinical failure of promising 
      neuroprotectants, numerous studies of brain ischaemia were carried out, with 
      physiopathological or pharmacological approaches refocused on the BBB, whose 
      structural complexity is now expanded to perivascular cells, all forming a 
      functional unit named the neurovascular unit (NVU). Nevertheless, in spite of the 
      numerous molecular mechanisms identified, the process of BBB dysfunction in the 
      ischaemia/reperfusion cascade remains insufficiently established to explain the 
      pleiotropic action exerted by new pharmacological compounds, possibly protecting 
      the entire NVU and representing potential treatments.
CI  - (c) Societe de Biologie, 2012.
FAU - Berezowski, Vincent
AU  - Berezowski V
AD  - UniversiteLille Nord de France, Lille, France. vincent.berezowski@univ-artois.fr
FAU - Mysiorek, Caroline
AU  - Mysiorek C
FAU - Kuntz, Melanie
AU  - Kuntz M
FAU - Petrault, Olivier
AU  - Petrault O
FAU - Cecchelli, Romeo
AU  - Cecchelli R
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - La barriere hemato-encephalique lors de l'ischemie cerebrale : une cible 
      therapeutique.
DEP - 20121122
PL  - France
TA  - Biol Aujourdhui
JT  - Biologie aujourd'hui
JID - 101544020
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Blood-Brain Barrier/*physiopathology
MH  - Brain Ischemia/*drug therapy
MH  - Endothelial Cells/physiology
MH  - Fibrinolytic Agents/adverse effects
MH  - Humans
MH  - Neuroprotective Agents
MH  - Reperfusion Injury/physiopathology
MH  - Stroke/drug therapy
MH  - Thrombolytic Therapy
EDAT- 2012/11/23 06:00
MHDA- 2013/02/08 06:00
CRDT- 2012/11/23 06:00
PHST- 2011/12/13 00:00 [received]
PHST- 2012/11/23 06:00 [entrez]
PHST- 2012/11/23 06:00 [pubmed]
PHST- 2013/02/08 06:00 [medline]
AID - jbio2012020 [pii]
AID - 10.1051/jbio/2012020 [doi]
PST - ppublish
SO  - Biol Aujourdhui. 2012;206(3):161-76. doi: 10.1051/jbio/2012020. Epub 2012 Nov 22.