PMID- 23172101
OWN - NLM
STAT- MEDLINE
DCOM- 20130802
LR  - 20130131
IS  - 1523-1755 (Electronic)
IS  - 0085-2538 (Linking)
VI  - 83
IP  - 2
DP  - 2013 Feb
TI  - Low mannose-binding lectin serum levels are associated with reduced kidney graft 
      survival.
PG  - 264-71
LID - 10.1038/ki.2012.373 [doi]
AB  - Activation of the complement system is initiated by the alternative, the 
      classical, or the lectin pathway. As the complement system is involved in the 
      pathophysiology of graft rejection after kidney transplantation, we investigated 
      the possible role of mannose-binding lectin in kidney transplantation and the 
      influence of human leukocyte antigen (HLA) immunization on this process. In a 
      prospective study of 544 kidney transplant patients over a follow-up period of 5 
      years, low serum levels of this lectin at the time of transplantation were found 
      to be significantly associated with decreased 5-year death-censored graft 
      survival (hazard ratio 1.68). Subanalysis showed that this association was 
      confined to non-HLA-immunized patients (hazard ratio 1.93). The strongest 
      association was seen in non-HLA-immunized patients receiving a kidney from a 
      deceased donor (hazard ratio 2.93). No significant association with 
      mannose-binding lectin levels and graft survival were found in HLA-immunized 
      patients. Variant MBL2 genotypes causing low mannose-binding lectin serum 
      concentrations showed the same association pattern. Our findings demonstrate a 
      clear protective role of mannose-binding lectin and thus innate immunity in 
      maintaining kidney graft survival, but these are probably overruled by HLA 
      immunization.
FAU - Bay, Jakob T
AU  - Bay JT
AD  - Department of Clinical Immunology, Laboratory of Molecular Medicine, 
      Rigshospitalet, Copenhagen, Denmark.
FAU - Sorensen, Soren S
AU  - Sorensen SS
FAU - Hansen, Jesper M
AU  - Hansen JM
FAU - Madsen, Hans O
AU  - Madsen HO
FAU - Garred, Peter
AU  - Garred P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121121
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (HLA Antigens)
RN  - 0 (MBL2 protein, human)
RN  - 0 (Mannose-Binding Lectin)
SB  - IM
CIN - Kidney Int. 2013 Feb;83(2):191-3. PMID: 23364585
MH  - Adult
MH  - Aged
MH  - Female
MH  - Genotype
MH  - *Graft Survival
MH  - HLA Antigens/immunology
MH  - Humans
MH  - Immunization
MH  - *Kidney Transplantation
MH  - Male
MH  - Mannose-Binding Lectin/*blood/genetics/physiology
MH  - Middle Aged
EDAT- 2012/11/23 06:00
MHDA- 2013/08/03 06:00
CRDT- 2012/11/23 06:00
PHST- 2012/11/23 06:00 [entrez]
PHST- 2012/11/23 06:00 [pubmed]
PHST- 2013/08/03 06:00 [medline]
AID - S0085-2538(15)55723-2 [pii]
AID - 10.1038/ki.2012.373 [doi]
PST - ppublish
SO  - Kidney Int. 2013 Feb;83(2):264-71. doi: 10.1038/ki.2012.373. Epub 2012 Nov 21.