PMID- 23174407
OWN - NLM
STAT- MEDLINE
DCOM- 20130509
LR  - 20221207
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 62
IP  - 4
DP  - 2013 Apr
TI  - High serum C1q-adiponectin/total adiponectin ratio correlates with coronary 
      artery disease in Japanese type 2 diabetics.
PG  - 578-85
LID - S0026-0495(12)00403-9 [pii]
LID - 10.1016/j.metabol.2012.10.011 [doi]
AB  - OBJECTIVE: Adiponectin, an adipocyte-derived protein, has potential 
      antiatherogenic properties. Low levels of serum total-adiponectin (Total-APN) 
      correlate with diabetes and coronary artery disease (CAD). Adiponectin and C1q 
      form a protein complex in blood, and serum C1q-binding adiponectin (C1q-APN) can 
      be measured. We investigated the correlation between C1q-APN and CAD in patients 
      with type 2 diabetes mellitus (T2DM). METHODS: The study subjects were 107 
      outpatients with T2DM who underwent evaluation for CAD. Blood C1q, Total-APN, 
      high-molecular weight-adiponectin (HMW-APN) and C1q-APN were measured by 
      enzyme-linked immunosorbent assays. RESULTS: Serum levels of C1q-APN/Total-APN 
      ratio were higher in patients diagnosed with CAD (10.47+/-0.59, mean+/-SEM, n=54) 
      than those without CAD (8.88+/-0.60, n=53, p=0.0482). Age- and sex-adjusted 
      logistic regression analysis identified serum C1q-APN/Total-APN ratio and 
      hypertension as significant and independent determinants of CAD. A high serum 
      C1q-APN/Total-APN ratio was associated with 3.965-fold increase in CAD 
      prevalence. CONCLUSIONS: High serum C1q-APN/Total-APN ratio correlates with CAD 
      in T2DM.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Hirata, Ayumu
AU  - Hirata A
AD  - Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 
      Osaka, Japan.
FAU - Kishida, Ken
AU  - Kishida K
FAU - Nakatsuji, Hideaki
AU  - Nakatsuji H
FAU - Kobayashi, Hironori
AU  - Kobayashi H
FAU - Funahashi, Tohru
AU  - Funahashi T
FAU - Shimomura, Iichiro
AU  - Shimomura I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121120
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Adiponectin)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Albuminuria/epidemiology
MH  - Anthropometry
MH  - Asian People
MH  - Coronary Angiography
MH  - Coronary Artery Disease/*blood/*epidemiology
MH  - Creatinine/urine
MH  - Diabetes Mellitus, Type 2/*blood/*epidemiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Japan/epidemiology
MH  - Lipids/blood
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Tomography, X-Ray Computed
EDAT- 2012/11/24 06:00
MHDA- 2013/05/10 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/08/23 00:00 [received]
PHST- 2012/10/18 00:00 [revised]
PHST- 2012/10/18 00:00 [accepted]
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/05/10 06:00 [medline]
AID - S0026-0495(12)00403-9 [pii]
AID - 10.1016/j.metabol.2012.10.011 [doi]
PST - ppublish
SO  - Metabolism. 2013 Apr;62(4):578-85. doi: 10.1016/j.metabol.2012.10.011. Epub 2012 
      Nov 20.