PMID- 23174498
OWN - NLM
STAT- MEDLINE
DCOM- 20130404
LR  - 20181202
IS  - 1558-0768 (Electronic)
IS  - 1085-5629 (Linking)
VI  - 31
IP  - 4
DP  - 2012 Dec
TI  - Molecular diagnostics for ambiguous melanocytic tumors.
PG  - 274-8
LID - S1085-5629(12)00100-9 [pii]
LID - 10.1016/j.sder.2012.09.001 [doi]
AB  - Certain subsets of melanocytic neoplasms are difficult to classify because of 
      conflicting histologic features and the existence of a poorly defined 
      intermediate grade of melanocytic tumors. The integration of molecular diagnostic 
      information with a histologic impression may contribute significantly toward 
      improving classification. This review discusses the development of and advances 
      in molecular techniques, including comparative genomic hybridization and 
      fluorescence in situ hybridization (FISH) as diagnostic and prognostic tools for 
      melanocytic neoplasms. Further, we discuss how specific molecular aberrations 
      identified via FISH correlate with certain morphologies in melanocytic neoplasms. 
      We also examine the prognostic value of FISH in intermediate-grade melanocytic 
      tumors, particularly atypical Spitz tumors.
CI  - Copyright (c) 2012 Frontline Medical Communications. Published by Elsevier Inc. All 
      rights reserved.
FAU - Shahbain, Hilmy
AU  - Shahbain H
AD  - College of Science, Benedictine University, Lisle, IL, USA.
FAU - Cooper, Chelsea
AU  - Cooper C
FAU - Gerami, Pedram
AU  - Gerami P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Cutan Med Surg
JT  - Seminars in cutaneous medicine and surgery
JID - 9617260
SB  - IM
MH  - Comparative Genomic Hybridization
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Melanoma/*diagnosis/genetics/pathology
MH  - *Molecular Diagnostic Techniques
MH  - Nevus/*diagnosis/genetics
MH  - Nevus, Epithelioid and Spindle Cell/*diagnosis/genetics
MH  - Prognosis
MH  - Skin Neoplasms/*diagnosis/genetics/pathology
EDAT- 2012/11/24 06:00
MHDA- 2013/04/05 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/08/16 00:00 [received]
PHST- 2012/09/05 00:00 [accepted]
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/04/05 06:00 [medline]
AID - S1085-5629(12)00100-9 [pii]
AID - 10.1016/j.sder.2012.09.001 [doi]
PST - ppublish
SO  - Semin Cutan Med Surg. 2012 Dec;31(4):274-8. doi: 10.1016/j.sder.2012.09.001.