PMID- 23174515
OWN - NLM
STAT- MEDLINE
DCOM- 20130611
LR  - 20220321
IS  - 1472-1465 (Electronic)
IS  - 0007-1250 (Linking)
VI  - 202
IP  - 1
DP  - 2013 Jan
TI  - Cost-effectiveness of early intervention in first-episode psychosis: economic 
      evaluation of a randomised controlled trial (the OPUS study).
PG  - 35-41
LID - 10.1192/bjp.bp.112.112300 [doi]
AB  - BACKGROUND: Information about the cost-effectiveness of early intervention 
      programmes for first-episode psychosis is limited. AIMS: To evaluate the 
      cost-effectiveness of an intensive early-intervention programme (called OPUS) 
      (trial registration NCT00157313) consisting of enriched assertive community 
      treatment, psychoeducational family treatment and social skills training for 
      individuals with first-episode psychosis compared with standard treatment. 
      METHOD: An incremental cost-effectiveness analysis of a randomised controlled 
      trial, adopting a public sector perspective was undertaken. RESULTS: The mean 
      total costs of OPUS over 5 years (euro123,683, s.e. = 8970) were not significantly 
      different from that of standard treatment (euro148,751, s.e. = 13073). At 2-year 
      follow-up the mean Global Assessment of Functioning (GAF) score in the OPUS group 
      (55.16, s.d. = 15.15) was significantly higher than in standard treatment group 
      (51.13, s.d. = 15.92). However, the mean GAF did not differ significantly between 
      the groups at 5-year follow-up (55.35 (s.d. = 18.28) and 54.16 (s.d. = 18.41), 
      respectively). Cost-effectiveness planes based on non-parametric bootstrapping 
      showed that OPUS was less costly and more effective in 70% of the replications. 
      For a willingness-to-pay up to euro50,000 the probability that OPUS was 
      cost-effective was more than 80%. CONCLUSIONS: The incremental cost-effectiveness 
      analysis showed that there was a high probability of OPUS being cost-effective 
      compared with standard treatment.
FAU - Hastrup, Lene Halling
AU  - Hastrup LH
AD  - Region Zealand, Psychiatric Research Unit, Roskilde, Denmark. 
      lhhs@regionsjaelland.dk
FAU - Kronborg, Christian
AU  - Kronborg C
FAU - Bertelsen, Mette
AU  - Bertelsen M
FAU - Jeppesen, Pia
AU  - Jeppesen P
FAU - Jorgensen, Per
AU  - Jorgensen P
FAU - Petersen, Lone
AU  - Petersen L
FAU - Thorup, Anne
AU  - Thorup A
FAU - Simonsen, Erik
AU  - Simonsen E
FAU - Nordentoft, Merete
AU  - Nordentoft M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20121122
PL  - England
TA  - Br J Psychiatry
JT  - The British journal of psychiatry : the journal of mental science
JID - 0342367
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antipsychotic Agents/therapeutic use
MH  - Community Mental Health Services/*economics/organization & administration
MH  - Cost-Benefit Analysis
MH  - Denmark
MH  - Diagnosis-Related Groups/economics
MH  - Early Medical Intervention/*economics
MH  - Family Therapy/economics
MH  - Health Care Costs/*statistics & numerical data
MH  - Health Services/*statistics & numerical data
MH  - Humans
MH  - Intention to Treat Analysis
MH  - Middle Aged
MH  - *Outcome and Process Assessment, Health Care
MH  - Patient Care Team/economics
MH  - Patient Education as Topic/economics
MH  - Psychotic Disorders/*economics/therapy
MH  - Schizophrenia/economics/therapy
MH  - Single-Blind Method
MH  - Socialization
MH  - Young Adult
EDAT- 2012/11/24 06:00
MHDA- 2013/06/12 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - S0007125000273170 [pii]
AID - 10.1192/bjp.bp.112.112300 [doi]
PST - ppublish
SO  - Br J Psychiatry. 2013 Jan;202(1):35-41. doi: 10.1192/bjp.bp.112.112300. Epub 2012 
      Nov 22.