PMID- 23176203
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130102
LR  - 20211021
IS  - 1752-1947 (Electronic)
IS  - 1752-1947 (Linking)
VI  - 6
DP  - 2012 Nov 24
TI  - Severe optic neuritis in a patient with combined neuromyelitis optica spectrum 
      disease and primary Sjogren's syndrome: a case report.
PG  - 401
LID - 10.1186/1752-1947-6-401 [doi]
AB  - INTRODUCTION: Optic neuritis, although uncommon, can be the initial presentation 
      of Sjogren's syndrome. Coexisting Sjogren's syndrome has also been reported with 
      neuromyelitis optica spectrum disorder. This case report highlights the 
      association between the two diseases and the importance of rheumatological and 
      neurological evaluations in patients with such diagnoses. Distinction of 
      neuromyelitis optica with coexisting connective tissue disease has both 
      prognostic and therapeutic significance for the patient. CASE PRESENTATION: We 
      report a case of a 56-year-old Chinese woman who presented with bilateral 
      asymmetric visual loss secondary to optic neuritis. She was subsequently found to 
      be seropositive for neuromyelitis optica immunoglobulin G (NMO-IgG) 
      (anti-aquaporin-4 antibody) and was diagnosed with neuromyelitis optica spectrum 
      disorder. She also fulfilled the international criteria for Sjogren's syndrome. 
      Despite initial high dose immunosuppressive therapy, she failed to regain vision 
      in one eye. CONCLUSION: Patients presenting with optic neuritis and severe visual 
      loss should be screened for neuromyelitis optica and treated appropriately. 
      Neuromyelitis optica has been associated with systemic autoimmune diseases, in 
      particular Sjogren's syndrome, and current evidence indicates that they are two 
      distinct entities. We recommend that both diagnoses be considered in cases of 
      optic neuritis with severe visual loss.
FAU - Tan, Petrina
AU  - Tan P
AD  - National Healthcare Group Eye Institute, Tan Tock Seng Hospital, 11 Jalan Tan 
      Tock Seng, Singapore 308433, Singapore. petrina_tan@ttsh.com.sg.
FAU - Yu, Wai Yung
AU  - Yu WY
FAU - Umapathi, Thirugnanam
AU  - Umapathi T
FAU - Lim, Su-Ann
AU  - Lim SA
LA  - eng
PT  - Journal Article
DEP - 20121124
PL  - England
TA  - J Med Case Rep
JT  - Journal of medical case reports
JID - 101293382
PMC - PMC3533877
EDAT- 2012/11/28 06:00
MHDA- 2012/11/28 06:01
PMCR- 2012/11/24
CRDT- 2012/11/27 06:00
PHST- 2012/06/19 00:00 [received]
PHST- 2012/10/24 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2012/11/28 06:01 [medline]
PHST- 2012/11/24 00:00 [pmc-release]
AID - 1752-1947-6-401 [pii]
AID - 10.1186/1752-1947-6-401 [doi]
PST - epublish
SO  - J Med Case Rep. 2012 Nov 24;6:401. doi: 10.1186/1752-1947-6-401.